Fixed Cationic Lipids
Nucleic acid delivery is a focus area for therapeutic research across the globe.
Nucleic acid cargo such as DNA, mRNA, siRNA, and CRISPR/Cas-9 gene editing
technologies are negatively charged (anionic) and thus, to sequester and deliver the
cargo, the delivery system needs a positively charged (cationic) component. Unlike
ionizable lipids, fixed cationic lipids are constantly charged in biological environments
regardless of the pH.
Fixed cationic lipids have been proven to be good transfection agents in liposomes
and lipid nanoparticles. Generally considered non-toxic at lower concentrations,
these lipids do present some toxicity concerns when used in higher concentrations
due to the tetrasubstituted ammonium moiety. Avanti offers a wide range of proven
fixed cationic lipids such as DOTMA or DOTAP, but new, innovative cationic lipids are constantly being added. Check out our fixed cationic lipid offerings and fuel your lipid-based nucleic acid delivery research today!
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- BUY 790310 - Transfection Reagent I
- BUY 790326 - Fluorescent Transfection Reagent
- BUY 810890 - Fluorescent DOTAP
- BUY 850549 - DORI
- BUY 890200 - DC-6-14
- BUY 890700 - 12:0 EPC (Cl Salt)
- BUY 890701 - 14:0 EPC (Cl Salt)
- BUY 890702 - 16:0 EPC (Cl Salt)
- BUY 890703 - 18:0 EPC (Cl Salt)
- BUY 890704 - 18:1 EPC (Cl Salt)
- BUY 890705 - 16:0-18:1 EPC (Cl Salt)
- BUY 890717 - 14:1 EPC (Tf Salt)
- BUY 890718 - APL-718
- BUY 890719 - APL-719
- BUY 890810 - 18:0 DDAB
- BUY 890860 - 14:0 TAP
- BUY 890870 - 16:0 TAP
- BUY 890880 - 18:0 TAP
- BUY 890890 - 18:1 TAP (DOTAP)
- BUY 890895 - 18:1 TAP (DOTAP, MS Salt)
- BUY 890898 - DOTMA