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890860 | 14:0 TAP

1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt)

14:0 TAP

Chloroform

Size SKU Packaging Price
25mg 890860C-25mg 890860C-25mg 1 x 25mg 10mg/mL 2.5mL $217.25
200mg 890860C-200mg 890860C-200mg 2 x 100mg 25mg/mL 4mL $454.00
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200mg 890860P-200mg 890860P-200mg 1 x 200mg $454.00 454
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Info

14:0 TAP

1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C34H68NO4Cl
Percent Composition
C 69.17%, H 11.61%, Cl 6.01%, N 2.37%, O 10.84%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
197974-74-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
590.361
Exact Mass
589.484
Synonyms
1,2-ditetradecanoyl-3-trimethylammonium-propane (chloride salt)
DMTAP
Transition Temp
39.1°C (see Regelin et al)
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References

Lou G, Anderluzzi G, Tandrup Schmidt S, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson R, Roberts CW, O'Hagan DT, Baudner BC, Perrie Y. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J Control Release. 2020 Jun 30:S0168-3659(20)30362-X. doi: 10.1016/j.jconrel.2020.06.027. Epub ahead of print. PMID: 32619745.

 PubMed ID: 32619745

Kanwa N, De SK, Maity A, Chakraborty A. Interaction of aliphatic amino acids with zwitterionic and charged lipid membranes: hydration and dehydration phenomena. Phys Chem Chem Phys. 2020 Feb 14;22(6):3234-3244. doi: 10.1039/c9cp06188f. Epub 2020 Jan 29. PMID: 31994545.

 PubMed ID: 31994545

Tanaka M, Miyake H, Oka S, Maeda S, Iwasaki K, Mukai T. Effects of charged lipids on the physicochemical and biological properties of lipid-styrene maleic acid copolymer discoidal particles. Biochim Biophys Acta Biomembr. 2020 Jan 28;1862(5):183209. doi: 10.1016/j.bbamem.2020.183209. Epub ahead of print. PMID: 32004520.

 PubMed ID: 32004520

Li P, Shen Y, Wang L, Lu W, Li W, Chen K, Zhou Y, Shen L, Wei F, Zheng W. The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter. 2019 Apr 23. doi: 10.1039/c9sm00321e. [Epub ahead of print]

 PubMed ID: 31011740

Regelin, A.E., Fankhaenel, S., Gürtesch, L., Prinz, C., von Kiedrowski, G., Massing, U. (2000) Biophysical and lipofection studies of DOTAP analogs. Biochim Biophys Acta. 1464:151-64. [PubMed]

 PubMed ID: 10704929
Bicelle Preparation

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol

Certificates of Analysis

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