890860 | 14:0 TAP
1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt)
14:0 TAP
1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt)
DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.
Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.
CAS Registry Number is a Registered Trademark of the American Chemical Society
DMTAP
Lou G, Anderluzzi G, Tandrup Schmidt S, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson R, Roberts CW, O'Hagan DT, Baudner BC, Perrie Y. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J Control Release. 2020 Jun 30:S0168-3659(20)30362-X. doi: 10.1016/j.jconrel.2020.06.027. Epub ahead of print. PMID: 32619745.
PubMed ID: 32619745Kanwa N, De SK, Maity A, Chakraborty A. Interaction of aliphatic amino acids with zwitterionic and charged lipid membranes: hydration and dehydration phenomena. Phys Chem Chem Phys. 2020 Feb 14;22(6):3234-3244. doi: 10.1039/c9cp06188f. Epub 2020 Jan 29. PMID: 31994545.
PubMed ID: 31994545Tanaka M, Miyake H, Oka S, Maeda S, Iwasaki K, Mukai T. Effects of charged lipids on the physicochemical and biological properties of lipid-styrene maleic acid copolymer discoidal particles. Biochim Biophys Acta Biomembr. 2020 Jan 28;1862(5):183209. doi: 10.1016/j.bbamem.2020.183209. Epub ahead of print. PMID: 32004520.
PubMed ID: 32004520Li P, Shen Y, Wang L, Lu W, Li W, Chen K, Zhou Y, Shen L, Wei F, Zheng W. The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter. 2019 Apr 23. doi: 10.1039/c9sm00321e. [Epub ahead of print]
PubMed ID: 31011740Regelin, A.E., Fankhaenel, S., Gürtesch, L., Prinz, C., von Kiedrowski, G., Massing, U. (2000) Biophysical and lipofection studies of DOTAP analogs. Biochim Biophys Acta. 1464:151-64. [PubMed]
PubMed ID: 10704929Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol
- Certificate of Analysis (Lot No. 890860C-200MG-A-029 and 6358CNA029)
- Certificate of Analysis (Lot No. 890860C-25MG-A-029 and 6358CJA029)
- Certificate of Analysis (Lot No. 890860P-200MG-A-029 and 6358PNA029)
- Certificate of Analysis (Lot No. 890860P-200MG-B-029 and 6358PNB029)
- Certificate of Analysis (Lot No. 890860C-200MG-B-029 and 6358CNB029)
- Certificate of Analysis (Lot No. 890860C-25MG-A-030 and 6358CJA030)
- Certificate of Analysis (Lot No. 890860P-200MG-A-030 and 6358PNA030)
- Certificate of Analysis (Lot No. 890860C-25MG-B-030 and 6358CJB030)
- Certificate of Analysis (Lot No. 890860C-200MG-A-030 and 6358CNA030)
- Certificate of Analysis (Lot No. 890860P-200MG-B-030 and 6358PNB030)
- Certificate of Analysis (Lot No. 890860P-200MG-C-030 and 6358PNC030)
- Certificate of Analysis (Lot No. 890860P-200MG-D-030 and 6358PND030)
- Certificate of Analysis (Lot No. 890860C-25MG-D-030 and 6358CJD030)
- Certificate of Analysis (Lot No. 890860C-200MG-C-030 and 6358CNC030)
- Certificate of Analysis (Lot No. 890860P-200MG-E-030 and 6358PNE030)
- Certificate of Analysis (Lot No. 890860P-200MG-F-030 and 6358PNF030)