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890895 | 18:1 TAP (DOTAP, MS Salt)

1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt)

18:1 TAP (DOTAP, MS Salt)

Chloroform

Size SKU Packaging Price
25mg 890895C-25mg 890895C-25mg 1 x 25mg 10mg/mL 2.5mL $223.75
200mg 890895C-200mg 890895C-200mg 2 x 100mg 25mg/mL 4mL $468.00
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Powder

Size SKU Packaging Price
25mg 890895P-25mg 890895P-25mg 1 x 25mg $223.75 223.75
200mg 890895P-200mg 890895P-200mg 2 x 100mg $468.00 468
Request Bulk Pricing
Info

18:1 TAP (DOTAP, MS Salt)

1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Data
Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C43H83NO8S
Percent Composition
C 66.71%, H 10.81%, N 1.81%, O 16.53%, S 4.14%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
144189-73-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
774.186
Exact Mass
773.584
Synonyms
1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane (methyl sulfate salt)
DOTAP
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References

Yoshikawa N, Fumoto S, Nakashima M, Shimokawa K, Miyamoto H, Nishida K. The role of fibronectin in pulmonary gene transfer following intravenous administration of lipoplex in mice. Biol Pharm Bull. 2013;36(11):1807-13. doi: 10.1248/bpb.b13-00500. PMID: 24189424.

 PubMed ID: 24189424
Certificates of Analysis

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