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890702 | 16:0 EPC (Cl Salt)

1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

16:0 EPC (Cl Salt)

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10mg 890702P-10mg 890702P-10mg 1 x 10mg $170.70
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16:0 EPC (Cl Salt)

1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H85NO8PCl
Percent Composition
C 63.17%, H 10.73%, Cl 4.44%, N 1.75%, O 16.03%, P 3.88%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
328250-18-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
798.553
Exact Mass
797.57
Synonyms
1,2-dihexadecanoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
Solubility in Different Solvents
Soluble in DMSO at 1mg/mL, soluble in ethanol and Chloroform:Methanol:Water (65:25:4) at 5mg/mL
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References

Wang C, Luo Y, Li X, Zhang F, Wang F, Han X, Wang T, Beke-Somfai T, Lu X. Revealing Molecular-Level Interaction between a Polymeric Drug and Model Membrane Via Sum Frequency Generation and Microfluidics. Langmuir. 2020 Feb 18;36(6):1615-1622. doi: 10.1021/acs.langmuir.9b03676. Epub 2020 Feb 10. PMID: 31967838.

 PubMed ID: 31967838

Evans KO, Compton DL, Kim S, Appell M. Charged phospholipid effects on AAPH oxidation assay as determined using liposomes. Chem Phys Lipids. 2019 Feb 21;220:49-56. doi: 10.1016/j.chemphyslip.2019.02.004. [Epub ahead of print]

 PubMed ID: 30796887

Koynova, R., Tenchov, B., Wang, L., MacDonald, R.C. (2009) Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. Mol Pharm. 6:951-8. [PubMed]

PubMed ID: 19341312

Tenchov, B.G., Wang, L., Koynova, R., MacDonald, R.C. (2008) Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency. Biochim Biophys Acta. 1778:2405-12. [ PubMed]

PubMed ID: 18722340

Koynova, R., Tarahovsky, Y.S., Wang, L., MacDonald, R.C. (2007) Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA. Biochim Biophys Acta. 1768:375-86. [PubMed]

 PubMed ID: 17156744

Koynova, R., Wang, L., MacDonald, R.C. (2007) Synergy in lipofection by cationic lipid mixtures: superior activity at the gel-liquid crystalline phase transition. J Phys Chem B. 111:7786-95. [PubMed]

 PubMed ID: 17571876

Wang, L., MacDonald, R.C. (2007) Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells. Mol Pharm. 4:615-23. [PubMed]

 PubMed ID: 17408283
Certificates of Analysis

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