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890705 | 16:0-18:1 EPC (Cl Salt)

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

16:0-18:1 EPC (Cl Salt)

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Size SKU Packaging Price
10mg 890705P-10mg 890705P-10mg 1 x 10mg $170.70
25mg 890705P-25mg 890705P-25mg 1 x 25mg $216.25
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Chloroform

Size SKU Packaging Price
10mg 890705C-10mg 890705C-10mg 1 x 10mg 10mg/mL 1mL $170.70 170.7
25mg 890705C-25mg 890705C-25mg 1 x 25mg 10mg/mL 2.5mL $216.25 216.25
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Info

16:0-18:1 EPC (Cl Salt)

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Data
Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C44H87NO8PCl
Percent Composition
C 64.09%, H 10.63%, Cl 4.30%, N 1.70%, O 15.52%, P 3.76%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
328250-19-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
824.59
Exact Mass
823.586
Synonyms
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-ethylphosphocholine (chloride salt)
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References

Olechowska K, Mach M, Ha C-Wydro K, Wydro P. Studies on the Interactions of 2-Hydroxyoleic Acid with Monolayers and Bilayers Containing Cationic Lipid: Searching for the Formulations for More Efficient Drug Delivery to Cancer Cells. Langmuir. 2019 Jul 9;35(27):9084-9092. doi: 10.1021/acs.langmuir.9b01326. Epub 2019 Jun 27.

 PubMed ID: 31246038

Xunan Zhang, Wei Zong, Jialiang Wang, Mingdong Dong, Wenlong Cheng, Tianmeng Sun, and Xiaojun Han. Multicompartmentalized vesosomes containing DOX loaded liposomes and 5FU loaded liposomes for synergistic tumor treatment. New J. Chem., 2019,43, 4895-4899. doi: 10.1039/C9NJ00238C

Faneca H, Düzgüneş N, Pedroso de Lima MC. Suicide Gene Therapy for Oral Squamous Cell Carcinoma. Methods Mol Biol. 2019;1895:43-55. doi: 10.1007/978-1-4939-8922-5_4.

 PubMed ID: 30539528

Zong W, Thingholm B, Itel F, Schattling PS, Brodszkij E, Mayer D, Stenger S, Goldie KN, Han X, Städler B. Phospholipid-Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability. Langmuir. 2018 Jun 1. doi: 10.1021/acs.langmuir.8b01073. [Epub ahead of print]

 PubMed ID: 29776311

Koynova, R., Tenchov, B., Wang, L., MacDonald, R.C. (2009) Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. Mol Pharm. 6:951-8.

 PubMed ID: 19341312

Tenchov, B.G., Wang, L., Koynova, R., MacDonald, R.C. (2008) Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency. Biochim Biophys Acta. 1778:2405-12.

PubMed ID: 18722340

Koynova, R., Tarahovsky, Y.S., Wang, L., MacDonald, R.C. (2007) Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA. Biochim Biophys Acta. 1768:375-86.

PubMed ID: 17156744

Koynova, R., Wang, L., MacDonald, R.C. (2007) Synergy in lipofection by cationic lipid mixtures: superior activity at the gel-liquid crystalline phase transition. J Phys Chem B. 111:7786-95.

 PubMed ID: 18722340

Wang, L., MacDonald, R.C. (2007) Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells. Mol Pharm. 4:615-23.

PubMed ID: 17408283
Certificates of Analysis

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