Miscibility of Phospholipid Binary Mixtures

TEMPERATURE & MISCIBILITY KEY

Delta Tc. Liquid Crystalline Transition Temperature

P = Perfect. Ideal mixing and no broadening of the phase transition in the mixture.

H = High. Mixing ideal or very nearly so; phase transitions of mixture are markedly broader than those of the pure components.

M = Moderate. Phase diagram deviates markedly from ideal behavior, but the solidus curve is not flat over any significant range of compositions.

L = Low. Solidus curve in phase diagram is essentially flat over some range of compositions encompassing a region 20-50% wide over the X_B-axis.

VL = Very Low. Solidus curve is essentially flat over most of the range of compositions (along >50% of the X_B-axis).

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REFERENCES

• Thermotropic Phase Transitions of Pure Lipids in Model Membranes and Their Modifications by Membrane Proteins, Dr. John R. Silvius. Lipid-Protein Interactions. John Wiley & Sons, Inc., New York, 1982. Reprinted with permission from John Wiley & Sons, Inc.