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890701 | 14:0 EPC (Cl Salt)

1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

14:0 EPC (Cl Salt)

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10mg 890701P-10mg 890701P-10mg 1 x 10mg $165.70
25mg 890701P-25mg 890701P-25mg 1 x 25mg $210.00
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14:0 EPC (Cl Salt)

1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Data
Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C38H77NO8PCl
Percent Composition
C 61.47%, H 10.45%, Cl 4.78%, N 1.89%, O 17.24%, P 4.17%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
186492-53-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
742.447
Exact Mass
741.508
Synonyms
1,2-ditetradecanoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
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References

Evans KO, Compton DL, Kim S, Appell M. Charged phospholipid effects on AAPH oxidation assay as determined using liposomes. Chem Phys Lipids. 2019 Feb 21;220:49-56. doi: 10.1016/j.chemphyslip.2019.02.004. [Epub ahead of print]

 PubMed ID: 30796887

Koynova, R., Tenchov, B., Wang, L., MacDonald, R.C. (2009) Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. Mol Pharm. 6:951-8. [PubMed]

 PubMed ID: 19341312

Tenchov, B.G., Wang, L., Koynova, R., MacDonald, R.C. (2008) Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency. Biochim Biophys Acta. 1778:2405-12. [PubMed]

 PubMed ID: 18722340

Koynova, R., Tarahovsky, Y.S., Wang, L., MacDonald, R.C. (2007) Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA. Biochim Biophys Acta. 1768:375-86. [PubMed]

 PubMed ID: 17156744

Koynova, R., Wang, L., MacDonald, R.C. (2007) Synergy in lipofection by cationic lipid mixtures: superior activity at the gel-liquid crystalline phase transition. J Phys Chem B. 111:7786-95. [PubMed]

 PubMed ID: 17571876

Wang, L., MacDonald, R.C. (2007) Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells. Mol Pharm. 4:615-23. [PubMed]

 PubMed ID: 17408283
Bicelle Preparation

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol

Certificates of Analysis

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