Ionizable Lipids for Your Nucleic Acid Delivery Research

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Ionizable Lipids

At Avanti Research™, we know how important ionizable lipids are when it comes to delivering mRNA, siRNA, and other nucleic acids. Whether you’re developing the next mRNA vaccine, a gene therapy, or exploring new RNA therapeutics, lipid nanoparticles (LNPs) are the go-to delivery system — and ionizable lipids are a key part of making them work.

Ionizable lipids are designed to be pH-sensitive, which is essential for effective delivery. They stay neutral at physiological pH (around 7.4), helping your LNP formulation stay stable in circulation. But once the LNP is taken up by a cell and enters the more acidic endosome, these lipids become positively charged, which helps the particle escape into the cytosol and release its nucleic acid cargo. That pH-triggered charge shift is critical — it’s what makes efficient delivery possible.

One of the biggest factors to consider when choosing an ionizable lipid is its apparent pKa — basically, how it behaves in the context of the full LNP formulation. Most ionizable lipids used in FDA-approved therapeutics have apparent pKa values between 6.0 and 7.0. That range helps balance stability in the bloodstream with the ability to release cargo inside cells.

At Avanti, we offer a selection of high-purity ionizable lipids designed to support everything from early formulation screening to clinical development. With Avanti’s reputation for quality and reliability, you can feel confident using our lipids to advance your nucleic acid delivery research — wherever it takes you next.

Certest Ionizable Lipids

Ionizable Lipids

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