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890870 | 16:0 TAP

1,2-dipalmitoyl-3-trimethylammonium-propane (chloride salt)

16:0 TAP

Chloroform

Size SKU Packaging Price
25mg 890870C-25mg 890870C-25mg 1 x 25mg 10mg/mL 2.5mL $223.75
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Powder

Size SKU Packaging Price
25mg 890870P-25mg 890870P-25mg 1 x 25mg $223.75 223.75
200mg 890870P-200mg 890870P-200mg 1 x 200mg $468.00 468
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Info

16:0 TAP

1,2-dipalmitoyl-3-trimethylammonium-propane (chloride salt)

DOTAP is one of the most widely used cationic lipids for gene transfection applications. DOTAP is proven to be efficient for in vitro and in vivo transfection applications. Various analogues of TAP are available for structure-activity relationship studies.

Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004;21(4):257-317. doi: 10.1615/critrevtherdrugcarriersyst.v21.i4.10. PMID: 15638468.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C38H76NO4Cl
Percent Composition
C 70.60%, H 11.85%, Cl 5.48%, N 2.17%, O 9.90%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
139984-36-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
646.467
Exact Mass
645.546
Synonyms
1,2-dihexadecanoyl-3-trimethylammonium-propane (chloride salt)
Transition Temp
52.8°C (see Regelin et al)
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References

Liu L, Zhang M, Zhang Q, Jiang W. Graphene nanosheets damage the lysosomal and mitochondrial membranes and induce the apoptosis of RBL-2H3 cells. Sci Total Environ. 2020 Sep 10;734:139229. doi: 10.1016/j.scitotenv.2020.139229. Epub 2020 May 7. PMID: 32450398.

 PubMed ID: 32450398

Wang J, Li P, Yu Y, Fu Y, Jiang H, Lu M, Sun Z, Jiang S, Lu L, Wu MX. Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity. Science. 2020 Feb 21;367(6480):eaau0810. doi: 10.1126/science.aau0810. PMID: 32079747.

 PubMed ID: 32079747

Zhu B, Wei X, Song J, Zhang Q, Jiang W. Crystalline phase and surface coating of Al2O3 nanoparticles and their influence on the integrity and fluidity of model cell membranes. Chemosphere. 2020 Jan 8;247:125876. doi: 10.1016/j.chemosphere.2020.125876. Epub ahead of print. PMID: 31978652.

 PubMed ID: 31978652

Liufu C, Li Y, Tu J, Zhang H, Yu J, Wang Y, Huang P, Chen Z. Echogenic PEGylated PEI-Loaded Microbubble As Efficient Gene Delivery System. Int J Nanomedicine. 2019 Nov 15;14:8923-8941. doi: 10.2147/IJN.S217338. PMID: 31814720; PMCID: PMC6863126.

 PubMed ID: 31814720

Bilotto P, Lengauer M, Andersson J, Ramach U, Mears LLE, Valtiner M. Interaction Profiles and Stability of Rigid and Polymer-Tethered Lipid Bilayer Models at Highly Charged and Highly Adhesive Contacts. Langmuir. 2019 Sep 11. doi: 10.1021/acs.langmuir.9b01942. [Epub ahead of print]

 PubMed ID: 31475831

Matusovsky OS, Mansson A, Persson M, Cheng YS, Rassier DE. High-speed AFM reveals subsecond dynamics of cardiac thin filaments upon Ca2+ activation and heavy meromyosin binding. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16384-16393. doi: 10.1073/pnas.1903228116. Epub 2019 Jul 29.

 PubMed ID: 31358631

Tani Y, Kaneta T. Enhancement of optical force acting on vesicles via the binding of gold nanoparticles. R Soc Open Sci. 2019 May 15;6(5):190293. doi: 10.1098/rsos.190293. eCollection 2019 May.

 PubMed ID: 31218066

Fan CH, Wang TW, Hsieh YK, Wang CF, Gao Z, Kim A, Nagasaki Y, Yeh CK. Enhancing Boron Uptake in Brain Glioma by a Boron-Polymer/Microbubble Complex with Focused Ultrasound. ACS Appl Mater Interfaces. 2019 Mar 27;11(12):11144-11156. doi: 10.1021/acsami.8b22468. Epub 2019 Mar 18.

 PubMed ID: 30883079

Masanori Hirose, Shigenori Sugisaki, Keishi Suga, and Hiroshi Umakoshi. Detection of L-Proline-Catalyzed Michael Addition Reaction in Model Biomembrane. Journal of Chemistry. 2019 February 26;4926435:8. doi: 10.1155/2019/4926435

Dreier LB, Bonn M, Backus EHG. Hydration and Orientation of Carbonyl Groups in Oppositely Charged Lipid Monolayers on Water. J Phys Chem B. 2019 Feb 7;123(5):1085-1089. doi: 10.1021/acs.jpcb.8b12297. Epub 2019 Jan 23.

 PubMed ID: 30620302

Dreier LB, Bonn M, Backus EHG. Hydration and Orientation of Carbonyl Groups in Oppositely Charged Lipid Monolayers on Water. J Phys Chem B. 2019 Jan 8. doi: 10.1021/acs.jpcb.8b12297. [Epub ahead of print]

 PubMed ID: 30620602

Regelin, A.E., Fankhaenel, S., Gürtesch, L., Prinz, C., von Kiedrowski, G., Massing, U. (2000) Biophysical and lipofection studies of DOTAP analogs. Biochim Biophys Acta. 1464:151-64.

PubMed ID: 10704929

Suga K, Tauchi A, Ishigami T, Okamoto Y, Umakoshi H. Preferential Adsorption of l-Histidine onto DOPC/Sphingomyelin/3β-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol Liposomes in the Presence of Chiral Organic Acids. Langmuir. 2017 Apr 18;33(15):3831-3838. doi: 10.1021/acs.langmuir.6b03264. Epub 2017 Apr 4.

 PubMed ID: 28272888
Certificates of Analysis

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