870016 | 23:2 Diyne PC [DC(8,9)PC]
1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine
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23:2 Diyne PC [DC(8,9)PC]
1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine
- The UV wavelength for efficient polymerization of diacetylene-containing lipids is 254nm.
- Protect diacetylene phospholipids from light, especially in solution.
- Diacetylene phospholipids will spontaneously polymerize in solution. Store the lipid as a powder for maximum stability.
- Recommend storage at -20° C or less.
- It has been found that the photosensitivity of diacetylenic containing membranes is dependent upon its thermal history. Membranes composed of diacetylenic lipids are light sensitive when prepared below the phase trasition but become insensitive to light after the membranes are heated above the transition temperature (40°C). The membranes remain insensitive to light even after they are cooled to 25°C, and only when they are cooled to near 0°C is light sensitivity regained.
- Photopolymerization of diacetylenic and non-polymerizable lipid (DOPC, DSPC etc.) mixtures depends upon lipid miscibility. High degrees of polymerization cannot be achieved in lipid mixtures where the diacetylenic groups are diluted by other non-polymerizable lipids.
CAS Registry Number is a Registered Trademark of the American Chemical Society
DC8,9PC
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PubMed ID: 32390435Wang Q, He L, Fan D, Liang W, Fang J. Improving the anti-inflammatory efficacy of dexamethasone in the treatment of rheumatoid arthritis with polymerized stealth liposomes as a delivery vehicle. J Mater Chem B. 2020 Feb 4:10.1039/c9tb02538c. doi: 10.1039/c9tb02538c. Epub ahead of print. PMID: 32016224.
PubMed ID: 32016224Goshi M, Pytel N, Elbayoumi T. Partially Polymerized Phospholipid Vesicles for Efficient Delivery of Macromolecules. Methods Mol Biol. 2019;2000:267-277. doi: 10.1007/978-1-4939-9516-5_18.
PubMed ID: 31148021Tin Phan Nguy, Ryoma Hayakawa, Volkan Kilinc, Matthieu Petit, Jean-Manuel Raimundo, Anne Charrier, and Yutaka Wakayama. Stable operation of water-gated organic field-effect transistor depending on channel flatness, electrode metals and surface treatment. 2019 Jpn. J. Appl. Phys. 58 SDDH02.
Yinan Wang, Qingchuan Li, Ping Zhang, David O'Connor, Rajender S.Varma, Miao Yu, Deyi Hou. One-pot green synthesis of bimetallic hollow palladium-platinum nanotubes for enhanced catalytic reduction of p-nitrophenol. Journal of Colloid and Interface Science. 2019 Mar 15; 539 (161-167). doi: 10.1016/j.jcis.2018.12.053.
Hindley JW, Elani Y, McGilvery CM, Ali S, Bevan CL, Law RV, Ces O. Light-triggered enzymatic reactions in nested vesicle reactors. Nat Commun. 2018 Mar 15;9(1):1093. doi: 10.1038/s41467-018-03491-7.
PubMed ID: 29545566Punnamaraju S, You H, Steckl AJ. (2012) Triggered Release of Molecules across Droplet Interface Bilayer Lipid Membranes using Photopolymerizable Lipids. Langmuir. 2012 May 22;28(20):7657-64. doi: 10.1021/la3011663. Epub 2012 May 10.
PubMed ID: 22548362Colantonio S1, Simpson JT, Fisher RJ, Yavlovich A, Belanger JM, Puri A, Blumenthal R. Quantitative analysis of phospholipids using nanostructured laser desorption ionization targets. Lipids. 2011 May;46(5):469-77. doi: 10.1007/s11745-010-3493-1. Epub 2011 Feb 15.
PubMed ID: 21327726Yavlovich, A., Singh, A., Blumenthal, R., Puri, A. (2011) A novel class of photo-triggerable liposomes containing DPPC:DC(8,9)PC as vehicles for delivery of doxorubicin to cells. Biochim Biophys Acta. 1808:117-26.
PubMed ID: 20691151Yavlovich, A., Singh, A., Tarasov, S., Capala, J., Blumenthal, R., Puri, A. (2009) Design of liposomes containing photopolymerizable phospholipids for triggered release of contents. J Therm Anal Calorim. 98:97-104.
PubMed ID: 20160877Hayward, J.A., Chapman, D. (1984) Biomembrane surfaces as models for polymer design: the potential for haemocompatibility. Biomaterials. 5:135-142.
PubMed ID: 6375749Johnston, D.S., Sanghera, S., Pons, M. Chapman, D. (1980) Phospholipid Polymers-Synthesis and Spectral Characteristics. Biochim Biophys Acta. 602:57-69.
PubMed ID: 6893417Colantonio, S., Simpson, J.T., Fisher, R.J., Yavlovich, A., Belanger, J.M., Puri, A., Blumenthal, R. (2011) Quantitative analysis of phospholipids using nanostructured laser desorption ionization targets. Lipids. 2011 May;46(5):469-77. doi: 10.1007/s11745-010-3493-1. Epub 2011 Feb 15.
PubMed ID: 21327726- Certificate of Analysis (Lot No. 870016P-1G-A-044 and 6158PQA044)
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