700062 | stigmasterol
stigmasta-5,22-dien-3-ol
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stigmasterol
stigmasta-5,22-dien-3-ol
What Is Stigmasterol?
Stigmasterol is a plant sterol, a type of steroid that is found in various plant sources. Sterols are generally present at 0.1 percent levels in the majority of plant lipids. Sitosterol and stigmasterol are two sterols plants routinely produce, along with campesterol and cholesterol. These common plant sterols all aid in the development and stress management process of plants.
Where Is Stigmasterol Found?
Stigmasterol belongs to the group of phytosterols or major sterols, which are natural compounds structurally similar to cholesterol. It is commonly found in vegetables, fruits, nuts, seeds, and some vegetable oils. It is particularly abundant in soybean oil and other legume oils.
Stigmasterol has a similar structure to dietary cholesterol, with a few differences in the side chain. Its chemical structure includes a sterol nucleus and a side chain.
It is present in various plant-based foods and food additives, including soybeans, sunflower seeds, peanuts, corn oil, and many other fruits, vegetables, and nuts. Its concentration can vary depending on the plant source. A major sterol in plasma membranes of plant cells, stigmasterol plays a role in regulating cell proliferation.
A Potent Plant Sterol
Along with other plant sterols, stigmasterol has been studied for its potential health benefits. Some research suggests that plant sterols may help lower blood cholesterol levels, particularly low-density lipoprotein (LDL) cholesterol. As a result, stigmasterol is sometimes included in functional foods and dietary intake supplements designed to support heart health.
Applications
It has also been reported to have an anti-cancer effect against various cancers including but not limited to lung cancer cells, ovarian cancer cells, breast cancer cells, liver cancer cells, cervical cancer cells, and gastric cancer cells. As such, it has become a prominent molecule in the research and development of cancer therapy drugs. It has been shown to impede tumor growth in a variety of malignant tumors. Stigmasterol treatment has a significant effect in inhibiting the proliferation of gastric and gallbladder cancer cells in dose-dependent usage. In vivo, stigmasterol was shown to disrupt or suppress tumor angiogenesis and promote tumor cell apoptosis or programmed cell death.
Other bodies of evidence with high clinical efficacy have suggested that the excess accumulation of stigmasterol is a powerful, independent risk factor for cardiovascular disease. Its cardiovascular disease risk is linked not to cholesterol-driven atherosclerosis but cardiac fibrosis and inflammation.
Stigmasterol is believed to compete with cholesterol for absorption in the digestive system. When consumed, it can partially block the absorption of cholesterol, leading to a reduction in circulating cholesterol levels. It has also been found to lower plasma cholesterol levels and impede plant sterol absorption in rats.
Some research suggests that stigmasterol may have anti-inflammatory properties, which could contribute to some potential cardiovascular benefits.
Order highly purified stigmasterol powder from Avanti Research in 5mg packaging.
CAS Registry Number is a Registered Trademark of the American Chemical Society
D5-Stigmasterol
110801
Powered by BiozMonnier N, Furlan AL, Buchoux S, Deleu M, Dauchez M, Rippa S, Sarazin C. Exploring the Dual Interaction of Natural Rhamnolipids with Plant and Fungal Biomimetic Plasma Membranes through Biophysical Studies. Int J Mol Sci. 2019 Feb 26;20(5). pii: E1009. doi: 10.3390/ijms20051009.
PubMed ID: 30813553- Certificate of Analysis (Lot No. 700062P-5MG-D-011 and 5144PHD011)
- Certificate of Analysis (Lot No. 700062P-5MG-A-011 and 5144PHA011)
- Certificate of Analysis (Lot No. 700062P-5MG-B-011 and 5144PHB011)
- Certificate of Analysis (Lot No. 700062P-5MG-C-011 and 5144PHC011)
- Certificate of Analysis (Lot No. 700062P-5MG-E-011 and 5144PHE011)
- Certificate of Analysis (Lot No. 700062P-5MG-A-012 and 5144PHA012)
- Certificate of Analysis (Lot No. 700062P-5MG-F-011 and 5144PHF011)
- Certificate of Analysis (Lot No. 700062P-5MG-G-011 and 5144PHG011)
- Certificate of Analysis (Lot No. 700062P-5MG-B-012 and 5144PHB012)
- Certificate of Analysis (Lot No. 700062P-5MG-C-012 and 5144PHC012)
- Certificate of Analysis (Lot No. 700062P-5MG-D-012 and 5144PHD012)
- Certificate of Analysis (Lot No. 700062P-5MG-E-012 and 5144PHE012)
- Certificate of Analysis (Lot No. 700062P-5MG-F-012 and 5144PHF012)
