Sphingolipid Metabolism
Modification of the basic amino alcohol backbones gives rise to a large family of sphingolipids that play important roles in membrane biology and provide many bioactive metabolites that regulate cell function. This large family of sphingolipids varies in structure and function, but their creation and destruction are governed by common synthetic and catabolic pathways. They arise from a single entry point and converge to a final breakdown pathway. Metabolites of sphingolipids are responsible for various signaling and regulatory roles within cells. These metabolites are also linked to many diseases. Inhibitors of sphingolipid metabolism enzymes have been widely studied and investigated as possible drugs.
Canals, D., Perry, D. M., Jenkins, R. W., & Hannun, Y. A. (2011). Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. British journal of pharmacology, 163(4), 694–712. https://doi.org/10.1111/j.1476...
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Inhibitors
- BUY 857392 - (R)-FTY720-OMe
- BUY 857393 - THI
- BUY 857395 - GT-11
- BUY 860455 - N-C12-deoxysphingosine
- BUY 860456 - N-C16-deoxysphingosine
- BUY 860457 - N-C24:1-deoxysphingosine
- BUY 860461 - N-C12-desoxymethylsphinganine
- BUY 860462 - N-C16-deoxysphinganine
- BUY 860463 - N-C16-desoxymethylsphinganine
- BUY 860464 - N-C24:1-deoxysphinganine
- BUY 860465 - N-C24:1-desoxymethylsphinganine
- BUY 860466 - N-C12-desoxymethylsphingosine
- BUY 860467 - N-C16-desoxymethylsphingosine
- BUY 860468 - N-C24:1-desoxymethylsphingosine
- BUY 860470 - 1-deoxysphingosine
- BUY 860473 - 1-desoxymethylsphinganine
- BUY 860477 - 1-desoxymethylsphingosine
- BUY 860480 - C10 bisphosphonate
- BUY 860488 - Safingol
- BUY 860493 - 1-deoxysphinganine
- BUY 860771 - Enigmol(2S,3S,5S)
- BUY 860772 - N-C6-Enigmol(2S,3S,5S)
- BUY 860857 - N3C14SOBRAC
- BUY 870792 - D-threo-PPMP
- Internal Standards
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