857395 | GT-11
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide
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GT-11
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide
GT-11 Dihydroceramide Desaturase Inhibitor
GT-11, also N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide, is the first inhibitor of dihydroceramide desaturase, an enzyme that converts dihydroceramide into the bioactive compound ceramide.
Dihydroceramides desaturase is an enzyme involved in the biosynthesis of ceramides. Ceramides are important molecules in the structure of cell membranes that contribute to various cellular processes including cell signaling and apoptosis, also referred to as programmed cell death. By inhibiting the activity of dihydroceramides desaturase, GT-11 can affect the production of ceramides, altering various cellular processes and pathways in which ceramides are involved.
Application
GT-11 shows potential in use as a cell protective agent due to the proapoptotic and proinflammatory effect of ceramide. GT-11's ability to inhibit dihydroceramides desaturase activity could have several potential applications in neurological disorders like Parkinson's Disease, metabolic disorders, cancer therapy, and more.
Packaging
Turn to Avanti Research for clean, reliable GT-11 in 1 mg powder packaging.
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozMuñoz-Guardiola P, Casas J, Megías-Roda E, Solé S, Perez-Montoyo H, Yeste-Velasco M, Erazo T, Diéguez-Martínez N, Espinosa-Gil S, Muñoz-Pinedo C, Yoldi G, Abad JL, Segura MF, Moran T, Romeo M, Bosch-Barrera J, Oaknin A, Alfón J, Domènech C, Fabriàs G, Velasco G, Lizcano JM. The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2020 May 25:1-18. doi: 10.1080/15548627.2020.1761651. Epub ahead of print. PMID: 32397857.
PubMed ID: 32397857Triola G, Fabrias G, Dragusin M, Niederhausen L, Broere R, Llebaria A, van Echten-Deckert G. Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons. Mol Pharmacol. 2004 Dec;66(6):1671-8. doi: 10.1124/mol.104.003681. Epub 2004 Sep 15. PMID: 15371559.
PubMed ID: 15371559Orienti I, Francescangeli F, De Angelis ML, Fecchi K, Bongiorno-Borbone L, Signore M, Peschiaroli A, Boe A, Bruselles A, Costantino A, Eramo A, Salvati V, Sette G, Contavalli P, Zolla L, Oki T, Kitamura T, Spada M, Giuliani A, Baiocchi M, La Torre F, Melino G, Tartaglia M, De Maria R, Zeuner A. A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors. Cell Death Dis. 2019 Jul 23;10(7):529. doi: 10.1038/s41419-019-1775-y.
PubMed ID: 31332161- Certificate of Analysis (Lot No. 857395P-1MG-A-010 and 5834PGA010)
- Certificate of Analysis (Lot No. 857395P-1MG-B-010 and 5834PGB010)
- Certificate of Analysis (Lot No. 857395P-1MG-C-010 and 5834PGC010)
- Certificate of Analysis (Lot No. 857395P-1MG-D-010 and 5834PGD010)
- Certificate of Analysis (Lot No. 857395P-1MG-A-010 and 5834PGA010)
- Certificate of Analysis (Lot No. 857395P-1MG-G-010 and 5834PGG010)
- Certificate of Analysis (Lot No. 857395P-1MG-H-010 and 5834PGH010)
- Certificate of Analysis (Lot No. 857395P-1MG-I-010 and 5834PGI010)
- Certificate of Analysis (Lot No. 857395P-1MG-J-010 and 5834PGJ010)
