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857392 | (R)-FTY720-OMe

(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol

(R)-FTY720-OMe

Oil

Size SKU Packaging Price
1mg 857392O-1mg 857392O-1mg 1 x 1mg $190.20
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Info

(R)-FTY720-OMe

(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol

(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C20H35NO2
Percent Composition
C 74.72%, H 10.97%, N 4.36%, O 9.95%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1382486-90-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
321.497
Exact Mass
321.267
Synonyms
(R)-FTY720-methyl ether
ROME
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References

Watson, D.G., Tonelli, F., Alossaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cell Signal 25:1011-1017. [PubMed]

PubMed ID: 23314175

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R.J., Watson, D.G., Chan, E., Bittman, R., Pyne, N.J., Pyne, S. (2013). The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism. Br J Pharmacol. 168(6):1497-505. [PubMed]

 PubMed ID: 23113536

Lim, K.G., Sun, C., Bittman, R., Pyne, N.J., Pyne, S. (2011). (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal 23:1590-5. [PubMed]

 PubMed ID: 21620961
Certificates of Analysis

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