860462 | N-C16-deoxysphinganine
N-palmitoyl-1-deoxysphinganine (m18:0/16:0)

N-C16-deoxysphinganine
N-palmitoyl-1-deoxysphinganine (m18:0/16:0)
Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), this product is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-deoxyDHCer is not clearly understood at this time.
CAS Registry Number is a Registered Trademark of the American Chemical Society
N-C16-1-deoxy
DHCer
110960
Jiménez-Rojo N, Sot J, Busto JV, Shaw WA, Duan J, Merrill AH Jr, Alonso A, Goñi FM. Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells. Biophys J. 2014 Dec 16;107(12):2850-2859. doi: 10.1016/j.bpj.2014.10.010. PMID: 25517151; PMCID: PMC4269796.
PubMed ID: 25517151Pruett ST, Bushnev A, Hagedorn K, Adiga M, Haynes CA, Sullards MC, Liotta DC, Merrill AH Jr. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res. 2008 Aug;49(8):1621-39. doi: 10.1194/jlr.R800012-JLR200. Epub 2008 May 21. PMID: 18499644; PMCID: PMC2444003.
PubMed ID: 18499644Zitomer NC, Mitchell T, Voss KA, Bondy GS, Pruett ST, Garnier-Amblard EC, Liebeskind LS, Park H, Wang E, Sullards MC, Merrill AH Jr, Riley RT. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. J Biol Chem. 2009 Feb 20;284(8):4786-95. doi: 10.1074/jbc.M808798200. Epub 2008 Dec 18. PMID: 19095642; PMCID: PMC2643501.
PubMed ID: 19095642- Certificate of Analysis (Lot No. 860462P-1MG-A-010 and 5930PGA010)
- Certificate of Analysis (Lot No. 860462P-5MG-A-011 and 5930PHA011)
- Certificate of Analysis (Lot No. 860462P-1MG-B-011 and 5930PGB011)
- Certificate of Analysis (Lot No. 860462P-1MG-C-011 and 5930PGC011)