860493 | 1-deoxysphinganine
1-deoxysphinganine (m18:0)

1-deoxysphinganine
1-deoxysphinganine (m18:0)
CAS Registry Number is a Registered Trademark of the American Chemical Society
(2S,3R)-2-amino-3-hydroxy-octadecane
ES-285
1-deoxy SA
1-deoxySa
110884
Muilwijk M, Goorden SMI, Celis-Morales C, Hof MH, Ghauharali-van der Vlugt K, Beers-Stet FS, Gill JMR, Vaz FM, van Valkengoed IGM. Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults. BMJ Open Diabetes Res Care. 2020 May;8(1):e001003. doi: 10.1136/bmjdrc-2019-001003. PMID: 32376636; PMCID: PMC7228466.
PubMed ID: 32376636Wu J, Ma S, Sandhoff R, Ming Y, Hotz-Wagenblatt A, Timmerman V, Bonello-Palot N, Schlotter-Weigel B, Auer-Grumbach M, Seeman P, Löscher WN, Reindl M, Weiss F, Mah E, Weisshaar N, Madi A, Mohr K, Schlimbach T, Velasco Cárdenas RM, Koeppel J, Grünschläger F, Müller L, Baumeister M, Brügger B, Schmitt M, Wabnitz G, Samstag Y, Cui G. Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness. Immunity. 2019 Mar 23. pii: S1074-7613(19)30095-0. doi: 10.1016/j.immuni.2019.03.005. [Epub ahead of print]
PubMed ID: 30952607Dohrn, M.F., A. Othman, S.K. Hirshman, H. Bode, I. Alecu, E. Fahndrich, W. Karges, J. Weis, J.B. Schulz, T. Hornemann, and K.G. Claeys. (2015). Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy? Eur J Neurol 22:806-14, e55.
PubMed ID: 25623782Jimenez-Rojo, N., J. Sot, J.V. Busto, W.A. Shaw, J. Duan, A.H. Merrill Jr, A. Alonso, and F.M. Goni. (2014). Biophysical Properties of Novel 1-Deoxy-(Dihydro)ceramides Occurring in Mammalian Cells. Biophys J 107:2850-9.
PubMed ID: 25517151Penno, A., M.M. Reilly, H. Houlden, M. Laura, K. Rentsch, V. Niederkofler, E.T. Stoeckli, G. Nicholson, F. Eichler, R.H. Brown Jr, A. von Eckardstein, and T. Hornemann. (2010). Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. J Biol Chem 285:11178-87.
PubMed ID: 20097765Pruett, S.T., A. Bushnev, K. Hagedorn, M. Adiga, C.A. Haynes, M.C. Sullards, D.C. Liotta, and A.H. Merrill Jr. (2008). Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J Lipid Res 49:1621-39. [PubMed]
PubMed ID: 18499644Zitomer, N.C., T. Mitchell, K.A. Voss, G.S. Bondy, S.T. Pruett, E.C. Garnier-Amblard, L.S. Liebeskind, H. Park, E. Wang, M.C. Sullards, A.H. Merrill Jr, and R.T. Riley. (2009). Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.[Abstract]
PubMed ID: 19095642Alecu I, Othman A, Penno A, Saied EM, Arenz C, von Eckardstein A, Hornemann T.Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J Lipid Res. 2017 Jan;58(1):60-71. doi: 10.1194/jlr.M072421. Epub 2016 Nov 21.
PubMed ID: 27872144- Certificate of Analysis (Lot No. 860493P-10MG-A-013 and 5953PIA013)
- Certificate of Analysis (Lot No. 860493P-1MG-A-013 and 5953PGA013)
- Certificate of Analysis (Lot No. 860493P-1MG-B-013 and 5953PGB013)
- Certificate of Analysis (Lot No. 860493P-1MG-C-013 and 5953PGC013)
- Certificate of Analysis (Lot No. 860493P-10MG-B-013 and 5953PIB013)
- Certificate of Analysis (Lot No. 860493P-1MG-A-014 and 5953PGA014)
- Certificate of Analysis (Lot No. 860493P-1MG-B-014 and 5953PGB014)
- Certificate of Analysis (Lot No. 860493P-10MG-A-014 and 5953PIA014)
- Certificate of Analysis (Lot No. 860493P-1MG-C-014 and 5953PGC014)
- Certificate of Analysis (Lot No. 860493P-1MG-D-014 and 5953PGD014)
- Certificate of Analysis (Lot No. 860493P-10MG-B-014 and 5953PIB014)
- Certificate of Analysis (Lot No. 860493P-1MG-E-014 and 5953PGE014)
- Certificate of Analysis (Lot No. 860493P-1MG-F-014 and 5953PGF014)