860545 | C12 Lactosyl(ß) Ceramide (d18:1/12:0)
D-lactosyl-ß-1,1' N-lauroyl-D-erythro-sphingosine
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C12 Lactosyl(ß) Ceramide (d18:1/12:0)
D-lactosyl-ß-1,1' N-lauroyl-D-erythro-sphingosine
D-lactosyl-ß-1,1' N-lauroyl-D-erythro-sphingosine, commonly referred to as C12 Lactosyl(ß) Ceramide (d18:1/12:0), is a synthetic glycosphingolipid composed of a sphingosine backbone (d18:1), a lauroyl fatty acid chain (12:0), and a lactosyl sugar moiety. This ceramide is part of the lactosylceramide family, which plays an important role in cell membrane structure and function, particularly in cell signaling, adhesion, and differentiation processes.
Application
C12 Lactosyl(ß) Ceramide is especially significant in the study of membrane microdomains, known as lipid rafts, where it contributes to the organization and stabilization of these regions. These lipid rafts are critical for various cellular processes, including signal transduction and protein sorting.
Additionally, lactosylceramides have been implicated in the pathogenesis of several diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders, making C12 Lactosyl(ß) Ceramide a valuable tool in biomedical research.
This compound is utilized in research focused on understanding the role of glycosphingolipids in cellular mechanisms, offering insights into their involvement in health and disease. D-lactosyl-β-1,1′ N-lauroyl-D-erythro-sphingosine can be used as a lipid standard to measure the amount of lipid in planarians using mass spectrometry.
Packaging
Avanti Research provides C12 Lactosyl(ß) Ceramide (d18:1/12:0) in powder form in 5 mg packaging.
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CAS Registry Number is a Registered Trademark of the American Chemical Society
N-(dodecanoyl)-1-ß-lactosyl-sphing-4-enine
Powered by BiozBhadwal P, Dahiya D, Shinde D, Vaiphei K, Math RGH, Randhawa V, Agnihotri N. LC-HRMS based approach to identify novel sphingolipid biomarkers in breast cancer patients. Sci Rep. 2020 Mar 13;10(1):4668. doi: 10.1038/s41598-020-61283-w. PMID: 32170160; PMCID: PMC7070000.
PubMed ID: 32170160Iaea DB, Spahr ZR, Singh RK, Chan RB, Zhou B, Bareja R, Elemento O, Di Paolo G, Zhang X, Maxfield FR. Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158609. doi: 10.1016/j.bbalip.2020.158609. Epub 2020 Jan 7. PMID: 31917335; PMCID: PMC6996790.
PubMed ID: 31917335Thommen A, Werner S, Frank O, Philipp J, Knittelfelder O, Quek Y, Fahmy K, Shevchenko A, Friedrich BM, Jülicher F, Rink JC. Body size-dependent energy storage causes Kleiber's law scaling of the metabolic rate in planarians. Elife. 2019 Jan 4;8:e38187. doi: 10.7554/eLife.38187. PMID: 30608231; PMCID: PMC6320072.
PubMed ID: 30608231- Certificate of Analysis (Lot No. 860545P-25MG-A-014 and 5995PJA014)
- Certificate of Analysis (Lot No. 860545P-5MG-A-014 and 5995PHA014)
- Certificate of Analysis (Lot No. 860545P-25MG-B-014 and 5995PJB014)
- Certificate of Analysis (Lot No. 860545P-5MG-B-014 and 5995PHB014)
- Certificate of Analysis (Lot No. 860545P-5MG-C-014 and 5995PHC014)
- Certificate of Analysis (Lot No. 860545P-5MG-E-014 and 5995PHE014)
