890908 | 306Oi10
tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
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Product is provided for Research Use Only intended for seeking Food and Drug Administration’s (FDA) approval under The Hatch-Waxman Act (formally known as the Drug Price Competition and Patent Term Restoration Act of 1984).
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306Oi10
tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate
306Oi10 is a synthetic branched-tail ionizable lipid with a pKa of 6.4 that is predominantly used in the formation of LNPs with mRNA that target the liver. The branched-tail results in a ten-fold luciferase expression in mice compared to its linear counterpart. This finding shows that branched-tail ionizable lipids have a profound impact on surface ionization compared to lipids with linear tails. Certain LNP formulations result in increased surface ionization and more effective mRNA delivery.1
References:
1. K. A. Hajj, R. L. Ball, S. B. Deluty, S. R. Singh, D. Strelkova, C. M. Knapp, K. A. Whitehead, Small 2019, 15, 1805097. https://doi.org/10.1002/smll.201805097
CAS Registry Number is a Registered Trademark of the American Chemical Society
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