Section Menu

850870 | C12-200

1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)

C12-200

Product is provided for Research Use Only intended for seeking Food and Drug Administration’s (FDA) approval under The Hatch-Waxman Act (formally known as the Drug Price Competition and Patent Term Restoration Act of 1984).

This product is available for shipping within the United States only. International shipping is not available.

This product is synthesized on request. Direct purchase is disabled. Request a quote
Info

C12-200

1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)

C12-200 is considered a branched-chain ionizable lipidoid used to prepare lipid nanoparticles (LNPs) to deliver siRNA, saRNA, and mRNA primarily to the liver. Below is a sample of recent studies conducted using C12-200:

  • Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors1
  • Role of helper lipids in optimising nanoparticle formulations of self-amplifying RNA2
  • Bile-acid containing lipid nanoparticles enhance extrahepatic mRNA delivery3

References:

1. Shubaash Anthiya, Süleyman Can Öztürk, Hamdullah Yanik, Ece Tavukcuoglu, Adem Şahin, Dhrubajyoti Datta, Klaus Charisse, David Moreira Álvarez, María Isabel Loza, Alfonso Calvo, Einar Sulheim, Simon Loevenich, Geir Klinkenberg, Ruth Schmid, Muthiah Manoharan, Güneş Esendağlı, Maria Jose Alonso,Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors, Journal of Controlled Release, Volume 357,2023, Pages 67-83, ISSN 0168-3659,https://doi.org/10.1016/j.jcon....
(https://www.sciencedirect.com/...)

2. Beatriz D. Barbieri, David J. Peeler, Karnyart Samnuan, Suzanne Day, Kai Hu, Hadijatou J. Sallah, John S. Tregoning, Paul F. McKay, Robin J. Shattock,
The role of helper lipids in optimising nanoparticle formulations of self-amplifying RNA, Journal of Controlled Release,Volume 374, 2024, Pages 280-292, ISSN 0168-3659,
https://doi.org/10.1016/j.jcon....(https://www.sciencedirect.com/...)

3. Patel, S.K.; Billingsley, M.M.; Mukalel, A.J.; Thatte, A.S.; Hamilton, A.G.; Gong, N.; El-Mayta, R.; Safford, H.C.; Merolle, M.; Mitchell, M.J. Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery. Theranostics 2024, 14 (1), 1-16. DOI: 10.7150/thno.89913.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C70H145N5O5
Percent Composition
C 73.95%, H 12.86%, N 6.16%, O 7.04%
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
CAS Number
1220890-25-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1136.96
Exact Mass
1136.12
Downloads

Related Products

890908
306Oi10 306Oi10 Buy Now
890907
cKK-E12 cKK-E12 Buy Now

Cart

Item Price Qty.
${ item.sku }
Base Price: $${ (item.price - (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150))).toFixed(2) }
Custom Packaging: +${ (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150)).toFixed(2) }
Change Custom Packaging 		${ item.salePriceAsCurrency }
Subtotal: ${ cart.itemSubtotal|money }
${ adjustment.type }: ${ adjustment.name } ${ adjustment.amountAsCurrency }
${ adjustment.name } ${ adjustment.amountAsCurrency }
Order Total: ${ cart.totalPriceAsCurrency }
Have a promo code? Enter it in your cart to apply your discount and enjoy the savings on your purchase! Finalize Cart