860805 | PAzePC-d5
1-palmitoyl-2- azelaoyl-sn-glycero(d5)-3-phosphocholine
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Info
PAzePC-d5
1-palmitoyl-2- azelaoyl-sn-glycero(d5)-3-phosphocholine
| Oxidized phospholipids (OxPLs) are oxidation-specific epitopes that can arise through either enzymatic or non-enzymatic mechanisms. PAzePC, (1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine) plays a pivotal role in the intricate biosynthesis of phosphatidylcholine, which is vital for maintaining the structural integrity of cellular membranes. Its multifaceted functions extend to critical roles in cellular communication and neurotransmission processes. PAzePC is characterized by a unique azelaoyl fatty acid chain and is used extensively in membrane biophysics research. Its distinct structure makes it ideal for studying lipid interactions, lipid membranes, and membrane dynamics. Featuring carboxyl groups at the ends of its truncated sn-2 chains, this unique structure underpins its role as an oxidized lipid with significant implications in various biological contexts. PAzePC-d5 is the deuterated version which will enable the study of structure, dynamics, and function of this lipid within the cell. Applications: PAzePC is instrumental in lipid research and beyond, including serving as an oxidized lipid dopant in liposomes, facilitating investigations into the relationship between H2O2 permeation and lipid membrane structure. Additionally, PAzePC acts as a substrate for lysosomal phospholipase A2 studies, which is crucial for understanding the structural basis of enzyme inhibition by Zn2+. Researchers also utilize PAzePC in the preparation of large unilamellar vesicles (LUVs) and giant unilamellar vesicles (GUVs). These vesicles are essential tools in membrane biophysics and drug delivery research. Moreover, as a fatty acid modified lipid, PAzePC serves as a potential drug target for antipsychotic drugs and antimicrobial agents. This highlights its therapeutic potential in addressing neurodegenerative pathologies and inflammatory disorders. |
Data
No
No
| C33H59D5NO10P |
>99%
1 year
-20°C
CAS Number
3091879-94-3
CAS Registry Number is a Registered Trademark of the American Chemical Society
CAS Registry Number is a Registered Trademark of the American Chemical Society
670.88
670.46
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