Acyl Carnitine - Deuterated
Acylcarnitines are acyl esters of the quaternary ammonium compound carnitine. These esters are essential for the catabolism of fatty acids and maintenance of energy homeostasis in the human body. Acylcarnitines transport acyl groups from fatty acids into the mitochondria to generate energy. These molecules are capable of moving through the mitochondrial and cell membranes via a carnitine shuttle. There are several disorders that have been linked to acylcarnitine metabolic defects including various acyl-CoA dehydrogenase deficiencies. These defects typically manifest as encephalopathy, cardiomyopathy, and myopathy. Milder acylcarnitine abnormalities have been detected in diseases such as insulin resistance, cardiovascular disease, and Alzheimer's disease. Avanti offers deuterated acylcarnitine derivatives for use as standards when studying these molecules and their biological roles.
https://www.lipidmaps.org/resources/lipidweb/lipidweb_html/lipids/simple/carnitin/index.htm
Gerald Liew, Benita Tse, I-Van Ho, Nichole Joachim, Andrew White, Russell Pickford, David Maltby, Bamini Gopinath, Paul Mitchell, Ben Crossett; Acylcarnitine Abnormalities Implicate Mitochondrial Dysfunction in Patients With Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2020;61(8):32. doi: https://doi.org/10.1167/iovs.61.8.32.
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- BUY 870311 - L-carnitine-d9
- BUY 870321 - C18:1 L-carnitine-d9
- BUY 870322 - C18:2 L-carnitine-d9
- BUY 870323 - C16:0 L-carnitine-d9
- BUY 870324 - C18:0 L-carnitine-d9 (HCl salt)
- BUY 870325 - C14:0 L-carnitine-d9
- BUY 870326 - C12:0 L-carnitine-d9 (HCl salt)
- BUY 870327 - C10:0 L-carnitine-d9 (HCl salt)
- BUY 870328 - C8:0 L-carnitine-d9
- BUY 870329 - C6:0 L-carnitine-d9
- BUY 870330 - C5:0 L-carnitine-d9
- BUY 870331 - C4:0 L-carnitine-d9
- BUY 870332 - C3:0 L-carnitine-d9 (HCl Salt)
- BUY 870333 - C2:0 L-carnitine-d9
- BUY 870856 - C26 D,L-Carnitine-d9
- BUY 870857 - 24:0(d4) L-carnitine