Acyl Carnitine - Deuterated

Category Menu

Acyl Carnitine - Deuterated

Acylcarnitines are acyl esters of the quaternary ammonium compound carnitine. These esters are essential for the catabolism of fatty acids and maintenance of energy homeostasis in the human body. Acylcarnitines transport acyl groups from fatty acids into the mitochondria to generate energy. These molecules are capable of moving through the mitochondrial and cell membranes via a carnitine shuttle. There are several disorders that have been linked to acylcarnitine metabolic defects including various acyl-CoA dehydrogenase deficiencies. These defects typically manifest as encephalopathy, cardiomyopathy, and myopathy. Milder acylcarnitine abnormalities have been detected in diseases such as insulin resistance, cardiovascular disease, and Alzheimer's disease. Avanti offers deuterated acylcarnitine derivatives for use as standards when studying these molecules and their biological roles.

https://www.lipidmaps.org/resources/lipidweb/lipidweb_html/lipids/simple/carnitin/index.htm

Gerald Liew, Benita Tse, I-Van Ho, Nichole Joachim, Andrew White, Russell Pickford, David Maltby, Bamini Gopinath, Paul Mitchell, Ben Crossett; Acylcarnitine Abnormalities Implicate Mitochondrial Dysfunction in Patients With Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2020;61(8):32. doi: https://doi.org/10.1167/iovs.61.8.32.

Acyl Carnitine - Deuterated

Get Avanti News