793068 | 18:1 BMP (R, R’; 2,2’-isomer)
sn-(1- hydroxy -2- oleoyl)-glycerol-3-phospho-sn-3'-(1'- hydroxy -2'- oleoyl)-glycerol (ammonium salt)

18:1 BMP (R, R’; 2,2’-isomer)
sn-(1- hydroxy -2- oleoyl)-glycerol-3-phospho-sn-3'-(1'- hydroxy -2'- oleoyl)-glycerol (ammonium salt)
Bis(monoacylglycerol)phosphate (BMP) is an unusual, negatively charged glycerophospholipid that plays a critical role in maintaining endo-lysosomal homeostasis. BMP exists in multiple isomeric forms, distinguished by variations in fatty acyl chains and their positions on the sn-2 and sn-3 carbons of its two glycerol backbones. Among these, the sn-2:sn-2’ isomer is thought to be the biologically active form.
18:1 BMP is a pivotal lipid for studying the structure, dynamics, and homeostasis of lysosomes and endo-lysosomal pathways. Additionally, it plays a crucial role in cholesterol transport research, particularly in understanding cholesterol egress and its regulation within lysosomal compartments. As an enzymatic cofactor, 18:1 BMP facilitates lipid catabolism, especially through its interaction with glucocerebrosidase (GCase). Furthermore, it is instrumental in research on exosome biogenesis, shedding light on the role of lipids in exosome formation and intraluminal vesicle (ILV) trafficking.