900600 | PhotoClick Sphingosine
(2S,3R,E)-2-amino-13-(3-(pent-4-yn-1-yl)-3H-diazirin-3-yl)tridec-4-ene-1,3-diol
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PhotoClick Sphingosine
(2S,3R,E)-2-amino-13-(3-(pent-4-yn-1-yl)-3H-diazirin-3-yl)tridec-4-ene-1,3-diol
(2S,3R,E)-2-amino-13-(3-(pent-4-yn-1-yl)-3H-diazirin-3-yl)tridec-4-ene-1,3-diol and pacSphingosine, or PhotoClick Sphingosine, is a chemical probe used to study sphingolipid metabolism and protein-lipid interactions in cells. As a photosensitizing analog of sphingosine, it integrates into endogenous lipid metabolic pathways. Featuring a sphingosine backbone (d18:1), PhotoClick Sphingosine plays a vital role in cell membrane structure and signaling pathways.
Application
PhotoClick Sphingosine is a clickable analog of sphingosine containing a photoactivatable diazirine group and a terminal alkyne moiety. Upon photoactivation, the diazirine group enables cross-linking with interacting biomolecules, facilitating photoaffinity labeling (PAL). The alkyne moiety supports bioorthogonal labeling via azine-alkyne cycloaddition, allowing for fluorescent tagging of sphingosine-binding proteins.
These properties make PhotoClick Sphingosine a valuable tool for tracking lipid-protein interactions and studying sphingolipid metabolism in live cells.
Packaging
Avanti Research™ provides PhotoClick Sphingosine in powder (250µg, 500µg, and 1mg) to keep you going from research to production.
With over 50 years of experience, we’re ready to help you achieve greatness in your research.
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozHöglinger D. Bi- and Trifunctional Lipids for Visualization of Sphingolipid Dynamics within the Cell. Methods Mol Biol. 2019;1949:95-103. doi: 10.1007/978-1-4939-9136-5_8.
PubMed ID: 30790251Haberkant P, Stein F, Höglinger D, Gerl MJ, Brügger B, Van Veldhoven PP, Krijgsveld J, Gavin AC, Schultz C. Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions. ACS Chem Biol. 2016 Jan 15;11(1):222-30. doi: 10.1021/acschembio.5b00810. Epub 2015 Nov 25.
PubMed ID: 26555438- Certificate of Analysis (Lot No. 900600P-100UG-A-010 and 6388PDA010)
- Certificate of Analysis (Lot No. 900600P-250UG-A-010 and 6388PEA010)
- Certificate of Analysis (Lot No. 900600P-1MG-A-010 and 6388PGA010)
- Certificate of Analysis (Lot No. 900600-CONF-A-010 and 6388PWA010)
- Certificate of Analysis (Lot No. 900600P-250UG-B-010 and 6388PEB010)
- Certificate of Analysis (Lot No. 900600P-100UG-B-010 and 6388PDB010)
