780201 | 18:1 PE MCC

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)

18:1 PE MCC

Powder

Size SKU Packaging Price
25mg 780201P-25mg 780201P-25mg 1 x 25mg $739.25
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Chloroform

Size SKU Packaging Price
25mg 780201C-25mg 780201C-25mg 1 x 25mg 10mg/mL 2.5mL $739.25 739.25
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Info

18:1 PE MCC

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), or 18:1 PE MCC, is a maleimide-functionalized phospholipid that has two oleic acid (18:1) chains that are attached to a phosphoethanolamine (PE) headgroup. Designed for thiol-specific conjugation, this headgroup modified lipid allows proteins to securely attach to membranes without disrupting the bilayer’s integrity. As part of the reactive maleimide group, it is essential in biochemical and biophysical applications, especially studies that require targeted protein-lipid interactions.

Application

Maleimide-functionalized lipids like 18:1 PE MCC are essential in anchoring polypeptides to membranes without affecting the bilayer’s permeability or disturbing lipid packing. Their unique molecular structure enables advanced applications. It is a valuable component in targeted drug delivery research, thanks to the phosphoethanolamine headgroup’s ability to closely mimic native PE liposomes. It allows stable liposomal formulations while maintaining membrane activity.

Another notable feature of this product is its ability to integrate proteins into nanodiscs, as it supports cysteine coupling strategies for protein stabilization and functional analysis. Furthermore, the hydrophobic oleic acid tails facilitate incorporation into lipid bilayers that allow for fluorescence and biophysical analysis in single-molecule experiments.

Packaging

Avanti Research™ provides high-purity 18:1 PE MCC in 25mg packaging in powder form and chloroform to keep your research moving forward.

With over 50 years of research leading the way, we’re prepared to partner with you and ensure your projects meet the highest standards. For GMP-certified offerings, visit Croda Pharma for a wide range of products designed to meet the stringent pharmaceutical requirements and ensure safety, efficacy, and consistency.

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C53H90N2NaO11P
Percent Composition
C 64.61%, H 9.21%, N 2.84%, Na 2.33%, O 17.86%, P 3.14
Stability
1 Year
Storage Temperature
-20°C
CAS Number
384847-49-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
985.252
Exact Mass
984.618
Synonyms
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)
References

Lin JJ, O'Donoghue GP, Wilhelm KB, Coyle MP, Low-Nam ST, Fay NC, Alfieri KN, Groves JT. Membrane Association Transforms an Inert Anti-TCRβ Fab' Ligand into a Potent T Cell Receptor Agonist. Biophys J. 2020 Apr 23:S0006-3495(20)30341-6. doi: 10.1016/j.bpj.2020.04.018. Epub ahead of print. PMID: 32407684.

PubMed ID: 32407684

Márquez I, Díaz-Haro G, Vélez M. Surface Orientation and Binding Strength Modulate Shape of FtsZ on Lipid Surfaces. Int J Mol Sci. 2019 May 24;20(10). pii: E2545. doi: 10.3390/ijms20102545.

PubMed ID: 31137602
Certificates of Analysis

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