780201 | 18:1 PE MCC
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)

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18:1 PE MCC
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), or 18:1 PE MCC, is a maleimide-functionalized phospholipid that has two oleic acid (18:1) chains that are attached to a phosphoethanolamine (PE) headgroup. Designed for thiol-specific conjugation, this headgroup modified lipid allows proteins to securely attach to membranes without disrupting the bilayer’s integrity. As part of the reactive maleimide group, it is essential in biochemical and biophysical applications, especially studies that require targeted protein-lipid interactions.
Application
Maleimide-functionalized lipids like 18:1 PE MCC are essential in anchoring polypeptides to membranes without affecting the bilayer’s permeability or disturbing lipid packing. Their unique molecular structure enables advanced applications. It is a valuable component in targeted drug delivery research, thanks to the phosphoethanolamine headgroup’s ability to closely mimic native PE liposomes. It allows stable liposomal formulations while maintaining membrane activity.
Another notable feature of this product is its ability to integrate proteins into nanodiscs, as it supports cysteine coupling strategies for protein stabilization and functional analysis. Furthermore, the hydrophobic oleic acid tails facilitate incorporation into lipid bilayers that allow for fluorescence and biophysical analysis in single-molecule experiments.
Packaging
Avanti Research™ provides high-purity 18:1 PE MCC in 25mg packaging in powder form and chloroform to keep your research moving forward.
With over 50 years of research leading the way, we’re prepared to partner with you and ensure your projects meet the highest standards. For GMP-certified offerings, visit Croda Pharma for a wide range of products designed to meet the stringent pharmaceutical requirements and ensure safety, efficacy, and consistency.
CAS Registry Number is a Registered Trademark of the American Chemical Society
Lin JJ, O'Donoghue GP, Wilhelm KB, Coyle MP, Low-Nam ST, Fay NC, Alfieri KN, Groves JT. Membrane Association Transforms an Inert Anti-TCRβ Fab' Ligand into a Potent T Cell Receptor Agonist. Biophys J. 2020 Apr 23:S0006-3495(20)30341-6. doi: 10.1016/j.bpj.2020.04.018. Epub ahead of print. PMID: 32407684.
PubMed ID: 32407684Márquez I, Díaz-Haro G, Vélez M. Surface Orientation and Binding Strength Modulate Shape of FtsZ on Lipid Surfaces. Int J Mol Sci. 2019 May 24;20(10). pii: E2545. doi: 10.3390/ijms20102545.
PubMed ID: 31137602- Certificate of Analysis (Lot No. 780201C-25MG-A-027 and 5236CJA027)
- Certificate of Analysis (Lot No. 780201P-100MG-A-028 and 5236PLA028)
- Certificate of Analysis (Lot No. 780201P-25MG-A-027 and 5236PJA027)
- Certificate of Analysis (Lot No. 780201C-25MG-A-028 and 5236CJA028)
- Certificate of Analysis (Lot No. 780201P-25MG-A-029 and 5236PJA029)
- Certificate of Analysis (Lot No. 780201C-25MG-A-029 and 5236CJA029)
- Certificate of Analysis (Lot No. 780201P-25MG-A-030 and 5236PJA030)
- Certificate of Analysis (Lot No. 780201C-25MG-A-030 and 5236CJ030)
- Certificate of Analysis (Lot No. 780201C-25MG-A-031 and 5236CJA031)
- Certificate of Analysis (Lot No. 780201P-25MG-E-030 and 5236PJE030)
- Certificate of Analysis (Lot No. 780201C-25MG-A-032 and 5236CJA032)
- Certificate of Analysis (Lot No. 780201P-25MG-A-032 and 5236CJA032)
- Certificate of Analysis (Lot No. 780201C-25MG-B-032 and 5236CJB032)
- Certificate of Analysis (Lot No. 780201P-25MG-B-032 and 5236CJB032)
- Certificate of Analysis (Lot No. 780201P-25MG-B-032 and 5236PJB032)
- Certificate of Analysis (Lot No. 780201P-25MG-A-032 and 5236PJA032)