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855675 | 16:0 Lyso PC

1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine

16:0 Lyso PC

Powder

Size SKU Packaging Price
25mg 855675P-25mg 855675P-25mg 1 x 25mg $149.50
200mg 855675P-200mg 855675P-200mg 1 x 200mg $192.00
500mg 855675P-500mg 855675P-500mg 1 x 500mg $300.00
1g 855675P-1g 855675P-1g 1 x 1g $526.77
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Chloroform

Size SKU Packaging Price
25mg 855675C-25mg 855675C-25mg 1 x 25mg 10mg/mL 2.5mL $149.50 149.5
200mg 855675C-200mg 855675C-200mg 2 x 100mg 25mg/mL 4mL $192.00 192
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Info

16:0 Lyso PC

1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine

16:0 Lyso PC, also known as 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine, is a remarkable phospholipase-mediated hydrolyzed phosphocholine. This lipid features a saturated fatty acid—palmitic acid (16:0)—as its tail, which is generated through the hydrolysis of the sn-2 acyl chain of phosphatidylcholine (PC) by phospholipase A2. A crucial component of oxidized low-density lipoprotein, 16:0 Lyso PC plays a significant role in inflammatory diseases and atherosclerosis and is a substrate for Autotaxin/LysoPLD, generating lysophosphatidic acid, which is essential for cell motility.

Application

The versatility of 16:0 Lyso PC makes it a powerful tool in various advanced research and therapeutic applications. In microbubble-mediated drug delivery, it enhances the efficiency of targeted therapy applications, particularly in cancer treatment. By integrating into microbubble technologies, 16:0 Lyso PC facilitates precise drug delivery to target sites, optimizing therapeutic outcomes.

Furthermore, its application in photodynamic therapy for glioma underscores its potential in medical treatments. Research has highlighted its role in biohybrid systems for light-activatable therapies, showing promise in treating challenging conditions like glioma. This innovative approach leverages 16:0 Lyso PC to improve clinical outcomes, showcasing its potential to enhance the effectiveness of photodynamic therapy.

Packaging

Avanti Research provides 16:0 Lyso PC in chloroform form in 25 mg and 200 mg packaging and in powder form in 25 mg, 200 mg, 500 mg, and 1 g packaging.

At Avanti Research, we are dedicated to supporting groundbreaking scientific research with top-tier products. Our commitment to excellence ensures that each batch of 16:0 Lyso PC meets the highest standards of purity and performance.


Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C24H50NO7P
Percent Composition
C 58.16%, H 10.17%, N 2.83%, O 22.60%, P 6.25%
Purity
>99% LPC; may contain up to 10% of the 2-LPC isomer
Stability
1 Years
Storage Temperature
-20°C
CAS Number
17364-16-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
495.63
Exact Mass
495.332
Synonyms
1-hexadecanoyl-sn-glycero-3-phosphocholine
PC(16:0/0:0)
110685
Solubility in Different Solvents
Insoluble in DMSO, soluble in ethanol at 1mg/mL, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL
CMC
4 - 8.3µM
Downloads
References

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Inglut CT, Baglo Y, Liang BJ, Cheema Y, Stabile J, Woodworth GF, Huang HC. Systematic Evaluation of Light-Activatable Biohybrids for Anti-Glioma Photodynamic Therapy. J Clin Med. 2019 Aug 21;8(9). pii: E1269. doi: 10.3390/jcm8091269.

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Yan Y, Du Z, Chen C, Li J, Xiong X, Zhang Y, Jiang H. Lysophospholipid profiles of apolipoprotein E-deficient mice reveal potential lipid biomarkers associated with atherosclerosis progression using validated UPLC-QTRAP-MS/MS-based lipidomics approach. J Pharm Biomed Anal. 2019 Jul 15;171:148-157. doi: 10.1016/j.jpba.2019.03.062. Epub 2019 Apr 5.

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Shchegravina ES, Tretiakova DS, Alekseeva AS, Galimzyanov TR, Utkin YN, Ermakov YA, Svirshchevskaya EV, Negrebetsky VV, Karpechenko NY, Chernikov VP, Onishchenko NR, Vodovozova EL, Fedorov AY, Boldyrev IA. Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects. Bioconjug Chem. 2019 Apr 17;30(4):1098-1113. doi: 10.1021/acs.bioconjchem.9b00051. Epub 2019 Mar 13.

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Shchegravina ES, Tretiakova DS, Alekseeva AS, Galimzyanov TR, Utkin YN, Ermakov YA, Svirshchevskaya EV, Negrebetsky VV, Karpechenko NY, Chernikov VP, Onishchenko NR, Vodovozova EL, Fedorov AY, Boldyrev IA. Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects. Bioconjug Chem. 2019 Mar 13. doi: 10.1021/acs.bioconjchem.9b00051. [Epub ahead of print]

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Takafumi Enomoto, Roberto Javier Brea, Ahanjit Bhattacharya, and Neal K Devaraj. In Situ Lipid Membrane Formation Triggered by an Intramolecular Photoinduced Electron Transfer. Langmuir, Just Accepted Manuscript

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