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850483 | 18:1 Cyanine 5 PC

1,2-dioleoyl-sn-glycero-3-phosphocholine-N-(Cyanine 5)

18:1 Cyanine 5 PC

Chloroform

Size SKU Packaging Price
250µg 850483C-250µg 850483C-250µg $270.00
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Info

18:1 Cyanine 5 PC

1,2-dioleoyl-sn-glycero-3-phosphocholine-N-(Cyanine 5)

Product Overview:

18:1 Cyanine 5 PC (Cyanine 5-Phosphatidylcholine) is a fluorescently labeled lipid that integrates the cyanine dye Cyanine 5 (a far-red fluorescent probe) with the phosphatidylcholine (PC) backbone, providing a versatile tool for molecular imaging and cellular tracking applications. Cyanine 5 is a fluorescent probe that emits near the infrared region and has good photostability. This probe allows for deep tissue penetration and minimal interference from biological autofluorescence, thus making 18:1 Cyanine 5 PC useful for in vivo imaging and real-time biological monitoring. Cyanine 5 probes are commonly used in applications such as cellular uptake studies, drug delivery tracking, and biomolecular interaction assays. Cyanine 5 PC is often conjugated with targeting ligands and therapeutic agents which enhances the precision and functionality of lipid nanocarriers in targeted therapy and diagnostic applications. Additionally, 18:1 Cyanine 5 PC has been used to track cell membrane dynamics and lipid bilayer behavior in real time.


Sources:

Mocan, T., et al. (2018). Cyanine-based fluorescent probes for molecular imaging: Synthesis and applications in biomedicine. Biomolecules, 8(4), 153.

Gupta, B., et al. (2020). Recent advancements in Cyanine 5 and Cyanine 5.5 conjugates for biomolecular imaging. Biochimica et Biophysica Acta (BBA) - General Subjects, 1864(7), 128474.

Li, H., et al. (2019). Real-time imaging of cellular interactions with Cy5-labeled liposomes for targeted drug delivery. Molecular Pharmaceutics, 16(10), 3764-3773.

Zhou, J., et al. (2020). In vivo fluorescence imaging using Cy5-labeled liposomes for cancer diagnosis and therapeutic monitoring. Journal of Nanobiotechnology, 18(1), 99.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C77H124ClN4O9P

Percent Composition

C 70.26%, H 9.50%, Cl 2.69%, N 4.26%, O 10.94%, P 2.35%

Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
2342573-49-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1316.26
Exact Mass
1314.88
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References

Benne N, Martins Cardoso R, Boyle AL, Kros A, Jiskoot W, Kuiper J, Bouwstra J, Van Eck M, Slütter B. Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques. Adv Healthc Mater. 2020 May;9(10):e2000043. doi: 10.1002/adhm.202000043. Epub 2020 Apr 24. PMID: 32329226.

 PubMed ID: 32329226
Certificates of Analysis

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