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SquareFluor™ Derivatives
SquareFluor™ (Squaraine) probes are defined by their unique squaric acid derived aromatic ring which leaves the probe vulnerable to nucleophilic attack which destroys its fluorescent ability. This glaring issue has historically prevented these probes from being studied as much as others, but they recent advancements in their synthetic design to overcome these issues has led to a re-emergence of their use. Squaraines are known to have extremely intense absorption bands and good photoconductivity while maintaining incredible photostability and a good quantum yield. Another key factor that makes Squaraine probes useful is that they can be synthesized with specific functional groups that target various biomolecules without compromising their photophysical properties. These properties make these probes promising in photodynamic therapy, bioimaging, and trace analyte sensors.