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841138 | Egg PG

L-α-phosphatidylglycerol (Egg, Chicken) (sodium salt)

Egg PG

Chloroform

Size SKU Packaging Price
25mg 841138C-25mg 841138C-25mg 1 x 25mg 10mg/mL 2.5mL $157.75
200mg 841138C-200mg 841138C-200mg 2 x 100mg 25mg/mL 4mL $450.00
500mg 841138C-500mg 841138C-500mg 5 x 100mg 25mg/mL 4mL $765.00
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Powder

Size SKU Packaging Price
25mg 841138P-25mg 841138P-25mg 1 x 25mg $157.75 157.75
200mg 841138P-200mg 841138P-200mg 2 x 100mg $450.00 450
500mg 841138P-500mg 841138P-500mg 5 x 100mg $765.00 765
Request Bulk Pricing
Info

Egg PG

L-α-phosphatidylglycerol (Egg, Chicken) (sodium salt)

Egg PG, L-α-phosphatidylglycerol (Egg, Chicken) (sodium salt), is a naturally occurring anionic phospholipid found in plant, animal, and bacterial cell membranes. While less abundant than phosphatidylethanolamine in prokaryotes and eukaryotes and phosphatidylcholine in eukaryotes, Egg PG plays a key part in numerous biological processes.

Phosphatidylglycerol is synthesized through a reaction between CDP-diglyceride and L-α-glycerol 3-phosphate, followed by dephosphorylation, making it a key metabolic precursor of cardiolipin. Structurally, PG comprises two acyl chains esterified to a glycerol backbone linked to a phosphate-containing headgroup carrying a negative charge. This structure allows PG to form the second largest lipid component of mammalian lung surfactant, comprising 10 percent of its lipids. Notably, PG levels are reduced in the lung surfactant of infants with respiratory distress syndrome.

Applications

Egg PG is valuable for many research applications. Its unique properties and critical functions make it an invaluable component in plant and animal studies, from investigating respiratory health to understanding photosynthetic processes.

It serves as an anionic phospholipid substrate in serial protein misfolding cyclic amplification (sPMCA) reactions, aiding in the study of protein dynamics. Researchers also use Egg PG in the preparation of large unilamellar vesicles (LUVs), which are crucial for examining membrane biophysics and protein-lipid interactions. Additionally, Egg PG is utilized as a standard in liquid chromatography-mass spectrometric (LC-MS) analysis, ensuring precise and accurate lipid quantification.

Packaging

Avanti Research offers Egg PG chloroform and powder form in 25 mg, 200 mg, and 500 mg packaging to successfully facilitate small-scale laboratory experiments and large-scale industrial applications.

Avanti's Egg PG is noted for its exceptional purity (>99%) and consistent performance, making it a reliable choice for critical research and development projects.


Data
Hygroscopic
Yes
Light Sensitive
Yes
Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
383907-64-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
782.284
Downloads
References

Hermal F, Frisch B, Specht A, Bourel-Bonnet L, Heurtault B. Development and characterization of layer-by-layer coated liposomes with poly(L-lysine) and poly(L-glutamic acid) to increase their resistance in biological media. Int J Pharm. 2020 Jun 24;586:119568. doi: 10.1016/j.ijpharm.2020.119568. Epub ahead of print. PMID: 32592900.

 PubMed ID: 32592900

Ramamourthy G, Park J, Seo C, J Vogel H, Park Y. Antifungal and Antibiofilm Activities and the Mechanism of Action of Repeating Lysine-Tryptophan Peptides against Candida albicans. Microorganisms. 2020 May 18;8(5):758. doi: 10.3390/microorganisms8050758. PMID: 32443520; PMCID: PMC7285485.

 PubMed ID: 32443520

Jacoberger-Foissac C, Saliba H, Wantz M, Seguin C, Flacher V, Frisch B, Heurtault B, Fournel S. Liposomes as tunable platform to decipher the antitumor immune response triggered by TLR and NLR agonists. Eur J Pharm Biopharm. 2020 Jul;152:348-357. doi: 10.1016/j.ejpb.2020.05.026. Epub 2020 May 29. PMID: 32479782.

 PubMed ID: 32479782

Lee SWL, Campisi M, Osaki T, Possenti L, Mattu C, Adriani G, Kamm RD, Chiono V. Modeling Nanocarrier Transport across a 3D In Vitro Human Blood-Brain-Barrier Microvasculature. Adv Healthc Mater. 2020 Apr;9(7):e1901486. doi: 10.1002/adhm.201901486. Epub 2020 Mar 3. PMID: 32125776.

 PubMed ID: 32125776

Mlynarczyk DT, Piskorz J, Popenda L, Stolarska M, Szczolko W, Konopka K, Jurga S, Sobotta L, Mielcarek J, Düzgüneş N, Goslinski T. S-seco-porphyrazine as a new member of the seco-porphyrazine family - Synthesis, characterization and photocytotoxicity against cancer cells. Bioorg Chem. 2020 Mar;96:103634. doi: 10.1016/j.bioorg.2020.103634. Epub 2020 Jan 30. PMID: 32044518.

 PubMed ID: 32044518

Staufer O, Schröter M, Platzman I, Spatz JP. Bottom-Up Assembly of Functional Intracellular Synthetic Organelles by Droplet-Based Microfluidics. Small. 2020 Feb 20:e1906424. doi: 10.1002/smll.201906424. Epub ahead of print. PMID: 32078238.

 PubMed ID: 32078238

Peschke M, Le Goff M, Koningstein GM, Vischer NO, Abdel-Rehim A, High S, van Ulsen P, Luirink J. Distinct Requirements for Tail-Anchored Membrane Protein Biogenesis in Escherichia coli. MBio. 2019 Oct 15;10(5). pii: e01580-19. doi: 10.1128/mBio.01580-19.

 PubMed ID: 31615956

Taneva SG, Lee J, Knowles DG, Tishyadhigama C, Chen H, Cornell RB. Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix. J Biol Chem. 2019 Oct 18;294(42):15517-15530. doi: 10.1074/jbc.RA119.009849. Epub 2019 Sep 4.

 PubMed ID: 31488547

Eto M, Hashimoto T, Shimizu T, Iwatsubo T. Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils. PLoS One. 2019 Jul 10;14(7):e0219465. doi: 10.1371/journal.pone.0219465. eCollection 2019.

 PubMed ID: 31291354

Hofmann T, Schmidt C. Instrument response of phosphatidylglycerol lipids with varying fatty acyl chain length in nano-ESI shotgun experiments. Chem Phys Lipids. 2019 Sep;223:104782. doi: 10.1016/j.chemphyslip.2019.05.007. Epub 2019 Jun 6.

 PubMed ID: 31176608

Thissa N. Siriwardena, Alexandre Lüscher, Thilo Köhler, Christian van Delden, Sacha Javor, Jean‐Louis Reymond. Antimicrobial Peptide Dendrimer Chimera. Helvetica. 2019 February 25;105(4). doi: 10.1002/hlca.201900034.

Jacoberger-Foissac C, Saliba H, Seguin C, Brion A, Kakhi Z, Frisch B, Fournel S, Heurtault B. Optimization of peptide-based cancer vaccine compositions, by sequential screening, using versatile liposomal platform. Int J Pharm. 2019 May 1;562:342-350. doi: 10.1016/j.ijpharm.2019.03.002. Epub 2019 Mar 15.

 PubMed ID: 30880104

Abbasi F, Su Z, Alvarez-Malmagro J, Leitch JJ, Lipkowski J. Effects of Amiloride, an Ion Channel Blocker, on Alamethicin Pore Formation in Negatively Charged, Gold-Supported, Phospholipid Bilayers: A Molecular View. Langmuir. 2019 Apr 9;35(14):5060-5068. doi: 10.1021/acs.langmuir.9b00187. Epub 2019 Mar 29

 PubMed ID: 30888178

Abbasi F, Alvarez-Malmagro J, Su Z, Leitch JJ, Lipkowski J. Pore Forming Properties of Alamethicin in Negatively Charged Floating Bilayer Lipid Membranes Supported on Gold Electrodes. Langmuir. 2018 Nov 1. doi: 10.1021/acs.langmuir.8b02554. [Epub ahead of print]

 PubMed ID: 30265810

Abbasi F, Alvarez Malmagro J, Su Z, Leitch JJ, Lipkowski J. Pore forming properties of alamethicin in negatively charged floating bilayer lipid membranes supported on gold electrodes. Langmuir. 2018 Sep 28. doi: 10.1021/acs.langmuir.8b02554. [Epub ahead of print]

 PubMed ID: 30265810

Metabolomics and lipidomics using traveling-wave ion mobility mass spectrometry, Giuseppe Paglia & Giuseppe Astarita Nature Protocols 12, 797-813 (2017) doi:10. 1038/nprot.2017.013 [PubMed]

 PubMed ID: 28301461
Fatty Acid Distribution

This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

841138FattyAcidDistribution.gif
Certificates of Analysis

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