840012 | Heart CA

Cardiolipin (Heart, Bovine) (sodium salt)

Heart CA

Chloroform

Size SKU Packaging Price
25mg 840012C-25mg 840012C-25mg 1 x 25mg 10mg/mL 2.5mL $162.50
50mg 840012C-50mg 840012C-50mg 1 x 50mg 25mg/mL 2mL $267.50
100mg 840012C-100mg 840012C-100mg 1 x 100mg 25mg/mL 4mL $451.00
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Powder

Size SKU Packaging Price
25mg 840012P-25mg 840012P-25mg 1 x 25mg $162.50 162.5
50mg 840012P-50mg 840012P-50mg 1 x 50mg $267.50 267.5
100mg 840012P-100mg 840012P-100mg 1 x 100mg $451.00 451
Request Bulk Pricing

Info

Heart CA

Cardiolipin (Heart, Bovine) (sodium salt)

Data
Hygroscopic
Yes
Light Sensitive
Yes
Purity
>99%
Stability
3 Months
Storage Temperature
-20°C
CAS Number
383907-10-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1494.319
Solubility in Different Solvents
Soluble in ethanol, DMSO, and Chloroform:Methanol:Water (73:23:3) at 5mg/mL
References

Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ, Vassallo N. Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin. Biochim Biophys Acta Biomembr. 2019 Sep 12:183064. doi: 10.1016/j.bbamem.2019.183064. [Epub ahead of print]

PubMed ID: 31521630

Pizzuto M, Lonez C, Baroja-Mazo A, Martínez-Banaclocha H, Tourlomousis P, Gangloff M, Pelegrin P, Ruysschaert JM, Gay NJ, Bryant CE. Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4. Cell Mol Life Sci. 2019 May 6. doi: 10.1007/s00018-019-03113-5.

PubMed ID: 31062071

Jacobs D, Hoogerheide DP, Rovini A, Jiang Z, Lee JC, Rostovtseva TK, Bezrukov SM. Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern. Sci Rep. 2019 Mar 14;9(1):4580. doi: 10.1038/s41598-019-40979-8.

PubMed ID: 30872688

Li M, Mandal A, Tyurin VA, DeLucia M, Ahn J, Kagan VE, van der Wel PCA. Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics. Structure. 2019 Mar 4. pii: S0969-2126(19)30051-6. doi: 10.1016/j.str.2019.02.007. [Epub ahead of print]

PubMed ID: 30879887

You DG, Cho YY, Lee HR, Lee JH, Yu SJ, Yoon JH, Yoo YD, Kim YJ, Lee GY. Hepatitis B virus X protein induces size-selective membrane permeabilization through interaction with cardiolipin. Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):729-737. doi: 10.1016/j.bbamem.2019.01.006. Epub 2019 Jan 16.

PubMed ID: 30658058

Flores-Romero H, Landeta O, Ugarte-Uribe B, Cosentino K, García-Porras M, García-Sáez AJ, Basañez G. BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL. Cell Death Differ. 2018 Dec 18. doi: 10.1038/s41418-018-0258-5. [Epub ahead of print]

PubMed ID: 30560933

Murad F, Garcia-Saez AJ. Quantification of the Interactions Between BCL-2 Proteins by Fluorescence Correlation Spectroscopy. Methods Mol Biol. 2019;1877:337-350. doi: 10.1007/978-1-4939-8861-7_20.

PubMed ID: 30636014

Mandal T, Hustedt EJ, Song L, Oh KJ. CW EPR and DEER Methods to Determine BCL-2 Family Protein Structure and Interactions: Application of Site-Directed Spin Labeling to BAK Apoptotic Pores. Methods Mol Biol. 2019;1877:257-303. doi: 10.1007/978-1-4939-8861-7_18.

PubMed ID: 30536012

Okamura K, Matsushita S, Kato Y, Watanabe H, Matsui A, Oka T, Matsuura T. In vitro synthesis of the human calcium transporter Letm1 within cell-sized liposomes and investigation of its lipid dependency. J Biosci Bioeng. 2018 Nov 28. pii: S1389-1723(18)30798-9. doi: 10.1016/j.jbiosc.2018.11.003. [Epub ahead of print]

PubMed ID: 30503650

Steer D, Leung SSW, Meiselman H, Topgaard D, Leal C. Structure of Lung-Mimetic Multilamellar Bodies with Lipid Compositions Relevant in Pneumonia. Langmuir. 2018 Jun 14. doi: 10.1021/acs.langmuir.8b01359. [Epub ahead of print]

PubMed ID: 29847137

Kurauskas V, Hessel A, Ma P, Lunetti P, Weinhäupl K, Imbert L, Brutscher B, King MS, Sounier R, Dolce V, Kunji ERS, Capobianco L, Chipot C, Dehez F, Bersch B, Schanda P. How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine. J Phys Chem Lett. 2018 Feb 8:933-938. doi: 10.1021/acs.jpclett.8b00269. [Epub ahead of print]

PubMed ID: 29397729
Fatty Acid Distribution

This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

840012FattyAcidDistribution.gif
Certificates of Analysis

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