330275 | Glycolithocholic acid-d4
5ß-cholanic acid-3α-ol N-(carboxymethyl)-amide-d4
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Glycolithocholic acid-d4
5ß-cholanic acid-3α-ol N-(carboxymethyl)-amide-d4
Glycolithocholic Acid-d4 is a deuterated variation of the bile acid (BA) glycolithocholic acid, meaning it bears a deuterium atom instead of a hydrogen atom. Deuterium is a stable isotope of hydrogen.
Glycolithocholic acid, also known as lithocholylglycine and glycolithocholate, is a physiologically occurring endogenous metabolite. It’s a derivative of lithocholic acid—a secondary BA with potent toxicity—that is obtained from the primary BA chenodeoxycholic acid in the colon. Lithocholic acid undergoes a process of conjugation with the amino acid glycine, resulting in the formation of glycolithocholic acid.
Glycolithocholic acid is most commonly used as a predictive marker for several diseases: ulcerative colitis, non-alcoholic steatohepatitis, and primary sclerosing cholangitis.
The levels of the glycine conjugate are found to be increased in the livers of rats on a diet, including ursodeoxycholic acid supplementation. Its plasma levels, on the other hand, are decreased after subcutaneous application of PEG-obestatin—a modified peptide hormone. Glycolithocholic acid levels also rise with age in children.
Its deuterated form, Glycolithocholic Acid-d4, is used as an internal standard for the quantification of glycolithocholic acid.
Choose Avanti’s stable isotope Glycolithocholic Acid-d4 for bile acid-conjugate research projects.
C26H39D4NO4
C 71.35%, H 10.82%, N 3.20%, O 14.62%
CAS Registry Number is a Registered Trademark of the American Chemical Society
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