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330275 | Glycolithocholic acid-d4

5ß-cholanic acid-3α-ol N-(carboxymethyl)-amide-d4

Glycolithocholic acid-d4

Methanol

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100µg 330275W-100µg 330275W-100µg $149.00
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1mg 330275P-1mg 330275P-1mg 1 x 1mg $203.94 203.94
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Info

Glycolithocholic acid-d4

5ß-cholanic acid-3α-ol N-(carboxymethyl)-amide-d4

Glycolithocholic Acid-d4 is a deuterated variation of the bile acid (BA) glycolithocholic acid, meaning it bears a deuterium atom instead of a hydrogen atom. Deuterium is a stable isotope of hydrogen.

Glycolithocholic acid, also known as lithocholylglycine and glycolithocholate, is a physiologically occurring endogenous metabolite. It’s a derivative of lithocholic acid—a secondary BA with potent toxicity—that is obtained from the primary BA chenodeoxycholic acid in the colon. Lithocholic acid undergoes a process of conjugation with the amino acid glycine, resulting in the formation of glycolithocholic acid.

Glycolithocholic acid is most commonly used as a predictive marker for several diseases: ulcerative colitis, non-alcoholic steatohepatitis, and primary sclerosing cholangitis.

The levels of the glycine conjugate are found to be increased in the livers of rats on a diet, including ursodeoxycholic acid supplementation. Its plasma levels, on the other hand, are decreased after subcutaneous application of PEG-obestatin—a modified peptide hormone. Glycolithocholic acid levels also rise with age in children.

Its deuterated form, Glycolithocholic Acid-d4, is used as an internal standard for the quantification of glycolithocholic acid.

Choose Avanti’s stable isotope Glycolithocholic Acid-d4 for bile acid-conjugate research projects.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H39D4NO4

Percent Composition

C 71.35%, H 10.82%, N 3.20%, O 14.62%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2044276-16-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
437.66
Exact Mass
437.34
Downloads
Certificates of Analysis

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