870128 | 16:0 DBCO PE

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl

16:0 DBCO PE

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25mg 870128P-25mg 870128P-25mg 1 x 25mg $457.50
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Info

16:0 DBCO PE

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl

16:0 DBCO PE is a functionalized lipid that combines the biocompatible properties of phosphatidylethanolamine (PE) with the reactive dibenzocyclooctyne (DBCO) group, enabling the use of click chemistry in various biomedical applications. By being a clickable lipid, it creates a versatile platform for creating functionalized lipid systems for drug delivery, molecular imaging, and targeted therapies. This lipid can be conjugated with targeting ligands such as fluorescent dyes or therapeutic agents offering precise targeting and controlled release of drugs. This lipid is also particularly valuable in creating nanoparticles for for cancer treatment and gene therapy.  

Sources:

Liu, Y., et al. (2017). Copper-free click chemistry for functionalization of lipid nanoparticles: A new approach to target-specific drug delivery. Journal of Controlled Release, 263, 9-18. 

Patra, A. R., et al. (2018). Liposomal formulations for targeted drug delivery: Advances in cancer treatment. International Journal of Nanomedicine, 13, 6399-6412.

Zhao, X., et al. (2021). Bioorthogonal functionalization of liposomes using DBCO-PE for targeted therapy and imaging applications. Biomaterials Science, 9(3), 767-778.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C56H90N3O10P
Percent Composition
C 67.51%, H 9.11%, N 4.22%, O 16.06%, P 3.11%
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
CAS Number
2260670-42-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
996.302
Exact Mass
995.636
References

Mayer SF, Ducrey J, Dupasquier J, Haeni L, Rothen-Rutishauser B, Yang J, Fennouri A, Mayer M. Targeting specific membranes with an azide derivative of the pore-forming peptide ceratotoxin A. Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):183023. doi: 10.1016/j.bbamem.2019.07.011. Epub 2019 Jul 17.

PubMed ID: 31325418
Certificates of Analysis

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