850528 | Mal(11.2)
tridecan-3-yloxy-ß-D-maltoside
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Mal(11.2)
tridecan-3-yloxy-ß-D-maltoside
This new class of detergents contain a short, branched alkyl chain at the interface between the polar head and the apolar tail. This design mimics the second aliphatic chain of lipid molecules and reduces water penetration, thereby increasing the hydrophobicity within the interior of the micelle. A detergent architecture of this style allows formation of smaller, more compact micelles which provides improved performance in the stabilization and crystallization of integral membrane proteins.
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozJiang X, Guan L, Zhou Y, Hong WX, Zhang Q, Kaback HR. Evidence for an intermediate conformational state of LacY. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E698-704. doi: 10.1073/pnas.1201107109. Epub 2012 Feb 21. PMID: 22355148; PMCID: PMC3311394.
PubMed ID: 22355148Hong WX, Baker KA, Ma X, Stevens RC, Yeager M, Zhang Q. Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26. Langmuir. 2010 Jun 1;26(11):8690-6. doi: 10.1021/la904893d. PMID: 20232919; PMCID: PMC2877156.
PubMed ID: 20232919- Certificate of Analysis (Lot No. 850528P-1G-A-010 and 5707PQA010)
