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850524 | CHEMS

cholesteryl hemisuccinate

CHEMS

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5g 850524P-5g 850524P-5g 1 x 5g $214.30
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Info

CHEMS

cholesteryl hemisuccinate

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C31H50O4
Percent Composition
C 76.50%, H 10.35%, O 13.15%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1510-21-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
486.726
Exact Mass
486.371
Synonyms
3β-Hydroxy-5-cholestene 3-hemisuccinate
5-Cholesten-3β-ol
3-hemisuccinate
CHS
Animal Source
Ovine
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References

Cruz N, Pinho JO, Soveral G, Ascensão L, Matela N, Reis C, Gaspar MM. A Novel Hybrid Nanosystem Integrating Cytotoxic and Magnetic Properties as a Tool to Potentiate Melanoma Therapy. Nanomaterials (Basel). 2020 Apr 6;10(4):693. doi: 10.3390/nano10040693. PMID: 32268611; PMCID: PMC7221742.

 PubMed ID: 32268611

Wang YQ, Ji MY, Wang C. Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy. Int J Pharm. 2020 May 30;582:119331. doi: 10.1016/j.ijpharm.2020.119331. Epub 2020 Apr 11. PMID: 32289484.

 PubMed ID: 32289484

Yao Y , Feng L , Wang Z , Chen H , Tan N . Programmed delivery of cyclopeptide RA-V and antisense oligonucleotides for combination therapy on hypoxic tumors and for therapeutic self-monitoring. Biomater Sci. 2019 Dec 17;8(1):256-265. doi: 10.1039/c9bm00905a. PMID: 31687671.

 PubMed ID: 31687671

Samaddar S, Mazur J, Boehm D, Thompson DH. Development And In Vitro Characterization Of Bladder Tumor Cell Targeted Lipid-Coated Polyplex For Dual Delivery Of Plasmids And Small Molecules. Int J Nanomedicine. 2019 Dec 4;14:9547-9561. doi: 10.2147/IJN.S225172. PMID: 31824150; PMCID: PMC6900316.

 PubMed ID: 31824150

Li Y, Zhai Y, Liu W, Zhang K, Liu J, Shi J, Zhang Z. Ultrasmall nanostructured drug based pH-sensitive liposome for effective treatment of drug-resistant tumor. J Nanobiotechnology. 2019 Nov 29;17(1):117. doi: 10.1186/s12951-019-0550-7. PMID: 31783863; PMCID: PMC6884872.

 PubMed ID: 31783863

Ramesh A, Brouillard A, Kumar S, Nandi D, Kulkarni A. Dual inhibition of CSF1R and MAPK pathways using supramolecular nanoparticles enhances macrophage immunotherapy. Biomaterials. 2020 Jan;227:119559. doi: 10.1016/j.biomaterials.2019.119559. Epub 2019 Oct 19.

 PubMed ID: 31670078

Ramesh A, Brouillard A, Kumar S, Nandi D, Kulkarni A. Dual inhibition of CSF1R and MAPK pathways using supramolecular nanoparticles enhances macrophage immunotherapy. Biomaterials. 2020 Jan;227:119559. doi: 10.1016/j.biomaterials.2019.119559. Epub 2019 Oct 19.

 PubMed ID: 31670078

Roth MS, Westcott DJ, Iwai M, Niyogi KK. Hexokinase is necessary for glucose-mediated photosynthesis repression and lipid accumulation in a green alga. Commun Biol. 2019 Sep 19;2:347. doi: 10.1038/s42003-019-0577-1. eCollection 2019.

 PubMed ID: 31552300

Mozumder S, Bej A, Srinivasan K, Mukherjee S, Sengupta J. Comprehensive structural modeling and preparation of human 5-HT2A G-protein coupled receptor in functionally active form. Biopolymers. 2019 Aug 30:e23329. doi: 10.1002/bip.23329. [Epub ahead of print]

 PubMed ID: 31469412

Kanamala M, Palmer BD, Jamieson SM, Wilson WR, Wu Z. Dual pH-sensitive liposomes with low pH-triggered sheddable PEG for enhanced tumor-targeted drug delivery. Nanomedicine (Lond). 2019 Aug;14(15):1971-1989. doi: 10.2217/nnm-2018-0510. Epub 2019 Jul 29.

 PubMed ID: 31355712

Dolstra CC, Rinker T, Sankhagowit S, Deng S, Ting C, Dang AT, Kuhl TL, Sasaki DY. Mechanism of Acid-Triggered Cargo Release from Lipid Bilayer-Coated Mesoporous Silica Particles. Langmuir. 2019 Aug 13;35(32):10276-10285. doi: 10.1021/acs.langmuir.9b01087. Epub 2019 Jul 22.

 PubMed ID: 31280569

Huang X, Chau Y. Investigating impacts of surface charge on intraocular distribution of intravitreal lipid nanoparticles. Exp Eye Res. 2019 Jun 22;186:107711. doi: 10.1016/j.exer.2019.107711. [Epub ahead of print]

 PubMed ID: 31238078

Kim H, Nobeyama T, Honda S, Yasuda K, Morone N, Murakami T. Membrane fusogenic high-density lipoprotein nanoparticles. Biochim Biophys Acta Biomembr. 2019 Jun 14. pii: S0005-2736(19)30139-7. doi: 10.1016/j.bbamem.2019.06.007. [Epub ahead of print]

 PubMed ID: 31207206

Ramesh, A., Natarajan, S.K., Nandi, D. et al. Dual Inhibitors-Loaded Nanotherapeutics that Target Kinase Signaling Pathways Synergize with Immune Checkpoint Inhibitor. Cel. Mol. Bioeng. (2019). doi: 10.1007/s12195-01900576-1

Pinho JO, Amaral JD, Castro RE, Rodrigues CM, Casini A, Soveral G, Gaspar MM. Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models. Nanomedicine (Lond). 2019 Apr;14(7):835-850. doi: 10.2217/nnm-2018-0388. Epub 2019 Mar 15.

 PubMed ID: 30875274

Thompson AA, Liu JJ, Chun E, Wacker D, Wu H, Cherezov V, Stevens RC. GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods. 2011 Dec;55(4):310-7. doi: 10.1016/j.ymeth.2011.10.011. Epub 2011 Oct 21.

 PubMed ID: 22041719
Bicelle Preparation

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol

Reference for Sterols for Bicelle-Like Micelles

Certificates of Analysis

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