890911 | Lipid 5
heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate
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Lipid 5
heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate
Lipid 5 is a synthetic ionizable lipid with a pKa value around 6.5 that is predominantly used in the formulation of LNPs to deliver messenger RNA (mRNA). Lipid 5 LNPs result in the expression of multiple proteins while also clearing from tissue quickly. Lipid 5 has been shown to accumulate predominantly in the liver and spleen with lesser amounts detected in the lungs and kidneys. Another key feature of Lipid 5 is its endosomal escape activity compared to other Ionizable lipids which is a measurement of how well a lipid can deliver cargo to the cytosol within a cell.1,2
References:
1. Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai, Tatiana Ketova, Joseph J. Senn, Andy Lynn, Alex Bulychev, Iain McFadyen, Joyce Chan, Örn Almarsson, Matthew G. Stanton, Kerry E. Benenato, A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates, Molecular Therapy, Volume 26, Issue 6, 2018, Pages 1509-1519, ISSN 1525-0016, https://doi.org/10.1016/j.ymth....
2. Sabnis S, Kumarasinghe ES, Salerno T, Mihai C, Ketova T, Senn JJ, Lynn A, Bulychev A, McFadyen I, Chan J, Almarsson Ö, Stanton MG, Benenato KE. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519. doi: 10.1016/j.ymthe.2018.03.010. Epub 2018 Mar 14. PMID: 29653760; PMCID: PMC5986714.
CAS Registry Number is a Registered Trademark of the American Chemical Society
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