890906 | Dlin-MC3-DMA
(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
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Dlin-MC3-DMA
(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
Dlin-MC3-DMA is a synthetic ionizable lipid with a pKa value around 6.4 that is predominantly used in the formation of LNPs for drug delivery. Dlin-MC3-DMA has been used clinically for the delivery of small interfering RNA (siRNA) and messenger RNA (mRNA). It has also been used for the transfection of plasmid DNA (pDNA) to the spleen in mice.1
References:
1. Jayaraman M, Ansell SM, Mui BL, Tam YK, Chen J, Du X, Butler D, Eltepu L, Matsuda S, Narayanannair JK, Rajeev KG, Hafez IM, Akinc A, Maier MA, Tracy MA, Cullis PR, Madden TD, Manoharan M, Hope MJ. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8529-33. doi: 10.1002/anie.201203263. Epub 2012 Jul 10. PMID: 22782619; PMCID: PMC3470698.
CAS Registry Number is a Registered Trademark of the American Chemical Society
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