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890900 | ALC-0315

6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium

ALC-0315

Oil

Size SKU Packaging Price
25mg 890900O-25mg 890900O-25mg 1 x 25mg $254.25
50mg 890900O-50mg 890900O-50mg 1 x 50mg $361.00
100mg 890900O-100mg 890900O-100mg 1 x 100mg $513.00
200mg 890900O-200mg 890900O-200mg 1 x 200mg $730.00
500mg 890900O-500mg 890900O-500mg 1 x 500mg $1,295.00
1g 890900O-1g 890900O-1g 1 x 1g $1,747.91
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Info

ALC-0315

6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium

6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium, or ALC-0315, is a highly specialized ionizable lipid engineered for LNP drug delivery systems. As a critical component in mRNA-based vaccines and gene therapies, it plays a significant role in nucleic acid encapsulation, intracellular delivery, and endosomal escape.

ALC-0315 is a cornerstone of modern RNA-based medicine, designed to optimize the stability and bioavailability of mRNA, siRNA, and CRISPR-based therapeutics.

Applications

ALC-0315 is a fundamental LNP component in mRNA-based vaccines used to ensure efficient payload protection and delivery. ALC-0315 also enables targeted nucleic acid delivery with low toxicity and high transfection efficiency crucial for RNA therapeutics.

This cationic lipid also enhances CRISPR, siRNA, and antisense oligonucleotide transport to facilitate precise gene modulation. Additionally, it is driving the development of next-generation RNA therapeutics by supporting advancements in oncology, rare disease treatment, and personalized medicine.

Packaging

Avanti Research™ provides ALC-0315 in powder (25mg, 50mg, 100mg, 200mg, 500mg, and 1g), so you can rest assured that products of the highest purity advance your research and development.

Our products are consistently created under carefully controlled conditions and to the highest purity level to ensure dependable results in your research and development.

If your research requires GMP-grade lipids, we’ve got you covered. Visit Croda Pharma to explore their GMP-certified options for high-purity pharmaceutical offerings that meet the strictest regulatory requirements.


Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C48H95NO5

Percent Composition

C 75.24%, H 12.50%, N 1.83%, O 10.44%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2036272-55-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
766.29
Exact Mass
765.72
Synonyms
CM04017
Solubility in Different Solvents
Insoluble in DMSO, soluble in ethanol and Chloroform:Methanol:Ammonia (90:10:0.5) at 5mg/mL
Downloads
References

Schoenmaker, Linde et al. “mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability.” International journal of pharmaceutics vol. 601 (2021): 120586. doi:10.1016/j.ijpharm.2021.120586

 PubMed ID: 33839230
Certificates of Analysis

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