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890813 | VSA 2

Semisynthetic Saponin Adjuvant-VSA 2

VSA 2

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Size SKU Packaging Price
1mg 890813P-1mg 890813P-1mg 1 x 1mg $243.92
5mg 890813P-5mg 890813P-5mg 1 x 5mg $975.65
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Info

VSA 2

Semisynthetic Saponin Adjuvant-VSA 2

*Use only for intended field-of-use in human and animal vaccination research.*

VSA-2 is a semisynthetic saponin adjuvant prepared from naturally occurring and readily available Momordica saponin and capable of stimulating antigen-specific humoral and cellular immune responses. It is prepared by incorporating a terminal-functionalized side chain to the branched trisaccharide domain at the C3 position of Momordica saponin II (MS II) isolated from the seeds of perennial Momordica cochinchinensis Spreng. Direct comparison of VSA-2 and the clinically proven saponin adjuvant QS-21 shows that VSA-2 is comparable to QS-21 in enhancing humoral and cellular immune responses.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C94H147NO42

Percent Composition

C 57.51%, H 7.55%, N 0.71%, O 34.23%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2489675-56-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1963.18
Exact Mass
1961.94
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References

J. Med. Chem. 2019, 62, 21, 9976–9982 Publication Date:October 28, 2019 https://doi.org/10.1021/acs.jmedchem.9b01511

J. Med. Chem. 2022, 65, 21, 14589–14598 Publication Date:November 1, 2022 https://doi.org/10.1021/acs.jmedchem.2c01087

J. Med. Chem. 2020, 63, 6, 3290–3297 Publication Date:February 26, 2020 https://doi.org/10.1021/acs.jmedchem.9b02063

Vaccines (Basel) 2022 Aug 24;10(9):1383. https://doi.org/10.3390/vaccines10091383

Front Immunol. 2022 Dec 12:13:1079047. https://doi.org/10.3389/fimmu.2022.1079047

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