890813 | VSA 2
VSA‑2 – Semisynthetic Saponin Adjuvant
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VSA 2
VSA‑2 – Semisynthetic Saponin Adjuvant
For use in research related to human and animal vaccination only.
VSA-2 is a semisynthetic saponin adjuvant engineered from Momordica saponin II (MS II), a compound derived from the seeds of Momordica cochinchinensis, a tropical climbing plant native to Southeast Asia. A functionalized side chain is introduced at the C3-position of its branched trisaccharide domain, creating a well-defined, high-purity immunostimulant. Its intended purpose is activating both humoral and cellular immune responses.
In preclinical studies, VSA-2 matches the immunogenic performance of QS-21, a widely used clinical adjuvant in animal models, offering equivalent consistency and scalability. It has enhanced lot-to-lot reproducibility, making it ideal for screening, dose optimization, and conjugate vaccine research.
Application
VSA-2 demonstrates the ability to improve antibody and T-cell responses in murine models across multiple antigen classes, including PCV13-based conjugate vaccines. Its compatibility with mRNA, protein, and polysaccharide vaccine formats enables it to serve as a reliable alternative to QS-21.
Packaging
Avanti Research™ provides VSA-2 as a lyophilized white powder in 1mg and 5mg research-grade packaging with custom and bulk quantities supplied upon request to support ongoing vaccine research.
As a trusted leader in the global scientific community, Avanti Research™ is committed to expanding its portfolio of high-performance immunological tools, such as VSA-2.
C94H147NO42
C 57.51%, H 7.55%, N 0.71%, O 34.23%
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozJ. Med. Chem. 2019, 62, 21, 9976–9982 Publication Date:October 28, 2019 https://doi.org/10.1021/acs.jmedchem.9b01511
J. Med. Chem. 2022, 65, 21, 14589–14598 Publication Date:November 1, 2022 https://doi.org/10.1021/acs.jmedchem.2c01087
J. Med. Chem. 2020, 63, 6, 3290–3297 Publication Date:February 26, 2020 https://doi.org/10.1021/acs.jmedchem.9b02063
Vaccines (Basel) 2022 Aug 24;10(9):1383. https://doi.org/10.3390/vaccines10091383
Front Immunol. 2022 Dec 12:13:1079047. https://doi.org/10.3389/fimmu.2022.1079047
- Certificate of Analysis (Lot No. 890813P-5MG-A-010 and 7277PHA010)
- Certificate of Analysis (Lot No. 890813P-1MG-A-010 and 7277PGA010)
