890812 | VSA 1

Semisynthetic Saponin Adjuvant-VSA 1

VSA 1

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Size SKU Packaging Price
1mg 890812P-1mg 890812P-1mg 1 x 1mg $236.82
5mg 890812P-5mg 890812P-5mg 1 x 5mg $947.25
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Info

VSA 1

Semisynthetic Saponin Adjuvant-VSA 1

*Use only for intended field-of-use in human and animal vaccination research.*

VSA-1 is a semisynthetic saponin adjuvant prepared from naturally occurring and readily available Momordica saponin and capable of stimulating antigen-specific humoral and cellular immune responses. Its immunostimulating activity in enhancing the immune responses induced by the clinical glycoconjugate pneumococcal vaccine PCV13 is compared with QS-21 in female BALB/c mice. Both VSA-1 and QS-21 boosted IgG and opsonic antibodies titers against seven selected serotypes, including serotypes 3, 14, and 19A that are involved in most PCV13 breakthroughs. 

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C88H145NO39

Percent Composition

C 57.41%, H 7.94%, N 0.76%, O 33.89%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2489675-55-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
1841.1
Exact Mass
1839.94
References

J. Med. Chem. 2019, 62, 21, 9976–9982 Publication Date:October 28, 2019 https://doi.org/10.1021/acs.jmedchem.9b01511


J. Med. Chem. 2022, 65, 21, 14589–14598 Publication Date:November 1, 2022 https://doi.org/10.1021/acs.jmedchem.2c01087


J. Med. Chem. 2020, 63, 6, 3290–3297 Publication Date:February 26, 2020 https://doi.org/10.1021/acs.jmedchem.9b02063


Vaccines (Basel) 2022 Aug 24;10(9):1383. https://doi.org/10.3390/vaccines10091383


Front Immunol. 2022 Dec 12:13:1079047. https://doi.org/10.3389/fimmu.2022.1079047


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