890812 | VSA 1
Semisynthetic Saponin Adjuvant-VSA 1
VSA 1
Semisynthetic Saponin Adjuvant-VSA 1
*Use only for intended field-of-use in human and animal vaccination research.*
VSA-1 is a semisynthetic saponin adjuvant prepared from naturally occurring and readily available Momordica saponin and capable of stimulating antigen-specific humoral and cellular immune responses. Its immunostimulating activity in enhancing the immune responses induced by the clinical glycoconjugate pneumococcal vaccine PCV13 is compared with QS-21 in female BALB/c mice. Both VSA-1 and QS-21 boosted IgG and opsonic antibodies titers against seven selected serotypes, including serotypes 3, 14, and 19A that are involved in most PCV13 breakthroughs.
C88H145NO39
C 57.41%, H 7.94%, N 0.76%, O 33.89%
CAS Registry Number is a Registered Trademark of the American Chemical Society
J. Med. Chem. 2019, 62, 21, 9976–9982 Publication Date:October 28, 2019 https://doi.org/10.1021/acs.jmedchem.9b01511
J. Med. Chem. 2022, 65, 21, 14589–14598 Publication Date:November 1, 2022 https://doi.org/10.1021/acs.jmedchem.2c01087
J. Med. Chem. 2020, 63, 6, 3290–3297 Publication Date:February 26, 2020 https://doi.org/10.1021/acs.jmedchem.9b02063
Vaccines (Basel) 2022 Aug 24;10(9):1383. https://doi.org/10.3390/vaccines10091383
Front Immunol. 2022 Dec 12:13:1079047. https://doi.org/10.3389/fimmu.2022.1079047