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880180 | C16 PEG2000 Ceramide

N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]}

C16 PEG2000 Ceramide

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Size SKU Packaging Price
25mg 880180P-25mg 880180P-25mg 1 x 25mg $551.75
200mg 880180P-200mg 880180P-200mg 1 x 200mg $1,176.00
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Info

C16 PEG2000 Ceramide

N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]}

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula

C129H253NO51 (average MW due to polydispersity of PEG)

Percent Composition

C 58.81%, H 9.68%, N 0.53%, O 30.97%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
212116-78-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2634.399
Exact Mass
2632.723
Solubility in Different Solvents
Soluble in ethanol, DMSO, and Chloroform:Methanol (9:1) at 5mg/mL
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References

Fattore L, Campani V, Ruggiero CF, Salvati V, Liguoro D, Scotti L, Botti G, Ascierto PA, Mancini R, De Rosa G, Ciliberto G. In Vitro Biophysical and Biological Characterization of Lipid Nanoparticles Co-Encapsulating Oncosuppressors miR-199b-5p and miR-204-5p as Potentiators of Target Therapy in Metastatic Melanoma. Int J Mol Sci. 2020 Mar 12;21(6):1930. doi: 10.3390/ijms21061930. PMID: 32178301; PMCID: PMC7139872.

 PubMed ID: 32178301

Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, Van Eygen H, Putteman E, Sami H, de Souza Carvalho-Wodarz C, Franzyk H, Nielsen HM, Braeckmans K, Lehr CM, Ogris M, Foged C. Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. J Control Release. 2019 Sep 28;310:82-93. doi: 10.1016/j.jconrel.2019.08.004. Epub 2019 Aug 6.

 PubMed ID: 31398360

Thanki K, Papai S, Lokras A, Rose F, Falkenberg E, Franzyk H, Foged C. Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery. Pharm Res. 2019 Jan 9;36(3):37. doi: 10.1007/s11095-018-2566-3.

 PubMed ID: 30623253

Maroof H, Islam F, Dong L, Ajjikuttira P, Gopalan V, McMillan NAJ, Lam AK. Liposomal Delivery of miR-34b-5p Induced Cancer Cell Death in Thyroid Carcinoma Cells. 2018 Dec 11;7(12). pii: E265. doi: 10.3390/cells7120265.

 PubMed ID: 30544959
Certificates of Analysis

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