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880155 | ALC-0159

Methoxypolyethyleneglycoloxy(2000)-N,N-ditetradecylacetamide

ALC-0159

Powder

Size SKU Packaging Price
25mg 880155P-25mg 880155P-25mg 1 x 25mg $128.75
50mg 880155P-50mg 880155P-50mg 1 x 50mg $221.50
100mg 880155P-100mg 880155P-100mg 1 x 100mg $386.00
200mg 880155P-200mg 880155P-200mg 1 x 200mg $620.00
500mg 880155P-500mg 880155P-500mg 1 x 500mg $1,025.00
1g 880155P-1g 880155P-1g 1 x 1g $1,884.90
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Info

ALC-0159

Methoxypolyethyleneglycoloxy(2000)-N,N-ditetradecylacetamide

Methoxypolyethyleneglycoloxy(2000)-N,N-ditetradecylacetamide, or ALC-0159, is a methoxypolyethylene glycol (PEG-2000) conjugated lipid and is designed to enhance the stability and biocompatibility of LNP drug delivery systems.

By forming a hydrophilic shield, ALC-0159 significantly reduces immune recognition to increase circulation time and improve bioavailability. As a key component in mRNA-based vaccines, this PEGylated lipid carries out a fundamental function in efficient nanoparticle encapsulation and intracellular delivery. This makes it indispensable in cutting-edge pharmaceutical and gene therapy applications.

Applications

ALC-0159 is a foundational element in LNPs for mRNA-based vaccines, including COVID-19 formulations. It is also vital for stabilizing nanoparticle formulations in nucleic acid and small-molecule drug delivery.

Other notable applications include its ability to improve stability, bioavailability, and reduced immunogenicity in CRISPR, siRNA, and antisense oligonucleotide uses, as well as driving next-generation RNA-based therapies, which enables improved systemic circulation and controlled release.

Packaging

Avanti Research™ provides ALC-0159 in powder (25mg, 50mg, 100mg, 200mg, 500mg, and 1g) for precise, reproducible results.

Trust Avanti to deliver industry-leading products that advance your research forward!

And whether you’re in preclinical research or commercial production, Croda Pharma can provide GMP-certified lipid options to meet your needs. Explore their pharmaceutical-grade offerings for high-quality, scalable solutions.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C121H243NO47

Percent Composition

C 58.98%, H 9.94%, N 0.57%, O 30.51%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1849616-42-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2464.24
Exact Mass
2462.67
Synonyms
770159
Solubility in Different Solvents
Soluble in ethanol, DMSO, and Chloroform:Methanol:Water (65:25:4) at 5mg/mL
Downloads
References

Schoenmaker, Linde et al. “mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability.” International journal of pharmaceutics vol. 601 (2021): 120586. doi:10.1016/j.ijpharm.2021.120586

 PubMed ID: 33839230
Certificates of Analysis

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