880134 | PMA
Polymethacrylate Copolymer (N−C4−52−6.9)
PMA
Polymethacrylate Copolymer (N−C4−52−6.9)
Perform Structure and Functional Studies on a Variety of Membrane Proteins
Advantages of PMA Based Lipid Nanodiscs:
PMA is more stable than SMA at lower pH and in the presence of divalent metal ions
PMA has a mild effect on lipid acyl chains
Spontaneously Forms Lipid Nanodiscs through Fragmentation of the Lipid Bilayer
Amenable to Biophysical Characterization using CD, UV/vis, and Fluorescence Spectroscopy
Ability to Product Nanodiscs of Various Sizes
Larger PMA Polymer Nanodiscs can be aligned in a magnetic field allowing for solid-state NMR studies on membrane proteins or peptides
C21H40NO6S+
Fraction of Butyl Methacrylate (BMA) in Copolymer: ~0.52
Fraction of Methyl Acryoloxy Choline (MAC) in Copolymer: ~0.48
Degree of Polymerization (DP): ~39.00
CAS Registry Number is a Registered Trademark of the American Chemical Society
Yasuhara K, Arakida J, Ravula T, Ramadugu SK, Sahoo B, Kikuchi JI, Ramamoorthy A. Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers. J Am Chem Soc. 2017 Dec 27;139(51):18657-18663. doi: 10.1021/jacs.7b10591. Epub 2017 Dec 5.
PubMed ID: 29171274- Certificate of Analysis (Lot No. 880134P-500MG-A-010 and 6569PPA010)
- Certificate of Analysis (Lot No. 880134P-100MG-A-010 and 6569PLA010)
- Certificate of Analysis (Lot No. 880134P-100MG-B-010 and 6569PLB010)
- Certificate of Analysis (Lot No. 880134P-100MG-C-010 and 6569PLC010)
- Certificate of Analysis (Lot No. 880134P-1G-A-010 and 6569PQA010)