DSPE-PEG(2000) Amine 880128 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt)

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Overview

DSPE-PEG(2000) Amine from Avanti Research™ is a (PEG) 2000-modified, DSPE-anchored phospholipid bearing a terminal primary amine, enabling versatile formulation conjugation strategies and surface functionalization of liposomes or lipid nanoparticles for drug delivery research.

The hydrophobic DSPE tail anchors the molecule within lipid bilayers, ensuring stable incorporation into liposomes or lipid nanoparticles, while the polyethylene glycol (PEG) polymer spacer chain provides hydrophilicity, steric stabilization, and increases its solubility when dispersed in aqueous media.

The amine end group serves as a reactive handle for coupling to activated esters, dyes, linkers, or targeting ligands, making this DSPE-PEG conjugate a versatile helper lipid for custom nanoparticle surface modification and supporting diverse bioconjugation workflows.

Applications

Labs researching and developing lipid-based drug delivery systems use Avanti Research™ DSPE-PEG(2000) Amine to introduce reactive amine groups onto the surface of liposomes, lipid nanoparticles, and related nanocarriers.

Once incorporated, the primary amine can be coupled to a wide range of molecules, supporting custom conjugation chemistry specific to the needs of the research system. This includes:

• Peptides, proteins, or affinity tags
• Fluorescent or imaging labels
• Crosslinkers, polymers, or linker scaffolds
• Preparation of targeted or imaging-enabled nanocarriers for binding or recognition studies

Formulation & handling

We offer DSPE-PEG(2000) Amine as an ammonium salt in chloroform and powder forms to support aqueous handling and micelle formation for post-insertion applications.

Avanti Research™ DSPE-PEG(2000) Amine is a high-purity (Purity >99%) composition (C₁₃₂H₂₆₆N₃O₅₄P; average MW due to polydispersity of PEG), confirmed by analytical validation; batch-specific certificates of analysis are available.

Handling procedures are as follows:

• Incorporate during lipid film hydration, microfluidic assembly, or post-insertion.
• Surface amine density is mol% dependent; adjust loading as needed.

• Store at −20°C, protected from moisture and light.

• Allow the product to warm to room temperature in the package before opening, weighing, or handling to prevent condensation.

Packaging and specifications

Avanti Research™ supplies DSPE-PEG(2000) Amine for research use only in pre-measured, quality-controlled quantities, accompanied by batch-specific certificates of analysis to support reproducibility and verify purity and composition identity.

For discussions regarding sublicenses or larger quantities, please email our customer service representatives at customerservice@avantiresearch.com.