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880126 | DSPE-PEG(2000) Maleimide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt)

DSPE-PEG(2000) Maleimide

Chloroform

Size SKU Packaging Price
25mg 880126C-25mg 880126C-25mg 1 x 25mg 10mg/mL 2.5mL $458.75
50mg 880126C-50mg 880126C-50mg 1 x 50mg 25mg/mL 2mL $794.00
100mg 880126C-100mg 880126C-100mg 1 x 100mg 25mg/mL 4mL $1,454.00
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Powder

Size SKU Packaging Price
10mg 880126P-10mg 880126P-10mg 1 x 10mg $241.30 241.3
25mg 880126P-25mg 880126P-25mg 1 x 25mg $458.75 458.75
50mg 880126P-50mg 880126P-50mg 1 x 50mg $794.00 794
100mg 880126P-100mg 880126P-100mg 1 x 100mg $1,454.00 1454
500mg 880126P-500mg 880126P-500mg 1 x 500mg $5,530.00 5530
Request Bulk Pricing
Info

DSPE-PEG(2000) Maleimide

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt)

Representative Structure

The molecular weight and exact mass are averages based on the polydispersity of PEG.

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula

C139H271N4O57P (average MW due to polydispersity of PEG)

Percent Composition

C 56.76%, H 9.29%, N 1.90%, O 31.00%, P 1.05%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
474922-22-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
2941.642
Exact Mass
2939.817
Synonyms
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-amino(polyethylene glycol)-2000-N’-(3-maleimidopropionyl)] (ammonium salt)
Solubility in Different Solvents
Soluble in ethanol, DMSO, and Chloroform:Methanol (85:15) at 5mg/mL
Downloads
References

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Gao Y, Zheng QC, Xu S, Yuan Y, Cheng X, Jiang S, Kenry, Yu Q, Song Z, Liu B, Li M. Theranostic Nanodots with Aggregation-Induced Emission Characteristic for Targeted and Image-Guided Photodynamic Therapy of Hepatocellular Carcinoma. Theranostics. 2019 Feb 12;9(5):1264-1279. doi: 10.7150/thno.29101. eCollection 2019.

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Meng Wang, Jun Song, Feifan Zhou, Ashley R. Hoover, Cynthia Murray, Benqing Zhou, Lu Wang, Junle Qu, Wei R. Chen. NIR‐Triggered Phototherapy and Immunotherapy via an Antigen‐Capturing Nanoplatform for Metastatic Cancer Treatment. Advanced Science. 2019 March 13. doi: 10.1002/advs.201802157

Constantinescu CA, Fuior EV, Rebleanu D, Deleanu M, Simion V, Voicu G, Escriou V, Manduteanu I, Simionescu M, Calin M. Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells. Pharmaceutics. 2019 Jan 21;11(1). pii: E47. doi: 10.3390/pharmaceutics11010047.

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Wei J, Sun J, Liu Y. Enhanced targeting of prostate cancer-initiating cells by salinomycin-encapsulated lipid-PLGA nanoparticles linked with CD44 antibodies. Oncol Lett. 2019 Apr;17(4):4024-4033. doi: 10.3892/ol.2019.10050. Epub 2019 Feb 19.

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Zheng T, Feng H, Liu L, Peng J, Xiao H, Yu T, Zhou Z, Li Y, Zhang Y, Bai X, Zhao S, Shi Y, Chen Y. Enhanced antiproliferative effect of resveratrol in head and neck squamous cell carcinoma using GE11 peptide conjugated liposome. Int J Mol Med. 2019 Feb 13. doi: 10.3892/ijmm.2019.4096. [Epub ahead of print]

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Feng C, Zhang H, Chen J, Wang S, Xin Y, Qu Y, Zhang Q, Ji W, Yamashita F, Rui M, Xu X. Ratiometric co-encapsulation and co-delivery of doxorubicin and paclitaxel by tumor-targeted lipodisks for combination therapy of breast cancer. Int J Pharm. 2019 Apr 5;560:191-204. doi: 10.1016/j.ijpharm.2019.02.009. Epub 2019 Feb 12.

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Karamched SR, Nosoudi N, Moreland HE, Chowdhury A, Vyavahare NR. Site-specific chelation therapy with EDTA-loaded albumin nanoparticles reverses arterial calcification in a rat model of chronic kidney disease. Sci Rep. 2019 Feb 22;9(1):2629. doi: 10.1038/s41598-019-39639-8.

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Li X, Xiao H, Lin C, Sun W, Wu T, Wang J, Chen B, Chen X, Cheng D. Synergistic effects of liposomes encapsulating atorvastatin calcium and curcumin and targeting dysfunctional endothelial cells in reducing atherosclerosis. Int J Nanomedicine. 2019 Jan 15;14:649-665. doi: 10.2147/IJN.S189819. eCollection 2019.

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Kim MW, Jeong HY, Kang SJ, Jeong IH, Choi MJ, You YM, Im CS, Song IH, Lee TS, Lee JS, Lee A, Park YS. Anti-EGF Receptor Aptamer-Guided Co-Delivery of Anti-Cancer siRNAs and Quantum Dots for Theranostics of Triple-Negative Breast Cancer. Theranostics. 2019 Jan 25;9(3):837-852. doi: 10.7150/thno.30228. eCollection 2019.

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Wang S, Wu W, Manghnani P, Xu S, Wang Y, Goh CC, Ng LG, Liu B. Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy. ACS Nano. 2019 Feb 18. doi: 10.1021/acsnano.8b08398. [Epub ahead of print]

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Gui K, Zhang X, Chen F, Ge Z, Zhang S, Qi X, Sun J, Yu Z. Lipid-polymer nanoparticles with CD133 aptamers for targeted delivery of all-trans retinoic acid to osteosarcoma initiating cells. Biomed Pharmacother. 2019 Mar;111:751-764. doi: 10.1016/j.biopha.2018.11.118. Epub 2019 Jan 3.

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Gaio Paradossi, Letizia Oddo, Barbara Cerroni, Carmit Ben-Harush, Eti Ariel, Francesco Di Meco, Zvi Ram, and Rachel Grossman. In Vivo Toxicity Study of Engineered Lipid Microbubbles in Rodents. ACS Omega, 2019, 4 (3), pp 5526–5533.

Accardo A, Mannucci S, Nicolato E, Vurro F, Diaferia C, Bontempi P, Marzola P, Morelli G. Easy formulation of liposomal doxorubicin modified with a bombesin peptide analogue for selective targeting of GRP receptors overexpressed by cancer cells. Drug Deliv Transl Res. 2019 Feb;9(1):215-226. doi: 10.1007/s13346-018-00606-x.

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Lin TW, Chien Y, Lin YY, Wang ML, Yarmishyn AA, Yang YP, Hwang DK, Peng CH, Hsu CC, Chen SJ, Chien KH. Establishing Liposome-Immobilized Dexamethasone-Releasing PDMS Membrane for the Cultivation of Retinal Pigment Epithelial Cells and Suppression of Neovascularization. Int J Mol Sci. 2019 Jan 9;20(2). pii: E241. doi: 10.3390/ijms20020241.

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Li M, Yang Y, Xu C, Wei J, Liu Y, Cun X, Yu Q, Tang X, Yin S, Zhang Z, He Q. Tumor-Targeted Chemoimmunotherapy with Immune-Checkpoint Blockade for Enhanced Anti-Melanoma Efficacy. AAPS J. 2019 Jan 11;21(2):18. doi: 10.1208/s12248-018-0289-3.

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