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870604 | oxPAPC

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine

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500µg 870604P-500ug 870604P-500ug $220.00
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oxPAPC

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine

oxPAPC, or Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, is a complex mixture of oxidized phospholipids that includes PGPC, POVPC, PEIPC, and others derived from the oxidation of synthetically pure 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC). 

To ensure purity and efficacy, unoxidized PAPC is carefully removed during the purification process. This transformation—driven by oxidation—imbues oxPAPC with unique biochemical properties, which makes it a powerful tool for studying lipid-mediated cellular responses and disease mechanisms.

Application

The oxidation of polyunsaturated fatty acids, whether enzymatically or non-enzymatically, produces oxylipins. These bioactive molecules are found in cell membranes, the extracellular matrix, and circulating plasma. Researchers have extensively studied oxPAPC, a key OxPL, for its role in inflammation, atherosclerosis, vascular aging, immune modulation, blood coagulation, and lung endothelial barrier regulation. 

Research indicates that endogenous OxPLs contribute to the pathogenesis of diseases such as liver fibrosis, non-alcoholic fatty liver disease, ischemia-reperfusion injury, and osteoporosis. However, their precise function remains context-dependent, exhibiting pro-inflammatory and protective roles depending on the biological setting. As a research-grade reagent, oxPAPC—along with TopFluor-oxPAPC (810318)—provides an indispensable tool for investigating lipid oxidation processes and their implications in disease and health.

Packaging

Avanti Research™ provides oxPAPC in powder (500µg) to keep your research going and provide the perfect tool to study key biological processes.

Our 50+ years of experience in lipid technology is at your service to make more breakthroughs that improve lives.

Data
Hygroscopic
No
Light Sensitive
No
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References

Hernández-Morales M, Shang T, Chen J, Han V, Liu C. Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep. 2020 Mar 10;30(10):3250-3260.e7. doi: 10.1016/j.celrep.2020.02.070. PMID: 32160534.

 PubMed ID: 32160534

Spickett, C.M., A. Reis, and A.R. Pitt. (2011). Identification of oxidized phospholipids by electrospray ionization mass spectrometry and LC-MS using a QQLIT instrument. Free Radic Biol Med 51:2133-49.

 PubMed ID: 21983435
Certificates of Analysis

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810318
TopFluor™-oxPAPC Buy Now

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