870129 | 18:1 DBCO PE
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl
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18:1 DBCO PE
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-dibenzocyclooctyl
Product Overview:
18:1 DBCO PE is a functionalized lipid that combines the biocompatible properties of phosphatidylethanolamine (PE) with the reactive dibenzocyclooctyne (DBCO) group, enabling the use of click chemistry in various biomedical applications. By being a clickable lipid, it creates a versatile platform for creating functionalized lipid systems for drug delivery, molecular imaging, and targeted therapies. This lipid can be conjugated with targeting ligands such as fluorescent dyes or therapeutic agents offering precise targeting and controlled release of drugs. This lipid is also particularly valuable in creating nanoparticles for for cancer treatment and gene therapy.
Sources:
Liu, Y., et al. (2017). Copper-free click chemistry for functionalization of lipid nanoparticles: A new approach to target-specific drug delivery. Journal of Controlled Release, 263, 9-18.
Patra, A. R., et al. (2018). Liposomal formulations for targeted drug delivery: Advances in cancer treatment. International Journal of Nanomedicine, 13, 6399-6412.
Zhao, X., et al. (2021). Bioorthogonal functionalization of liposomes using DBCO-PE for targeted therapy and imaging applications. Biomaterials Science, 9(3), 767-778.
Santiago, L. L., et al. (2019). Engineering liposomal systems with bioorthogonal chemistry for targeted drug delivery. Bioconjugate Chemistry, 30(9), 2496-2504.
CAS Registry Number is a Registered Trademark of the American Chemical Society
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- Certificate of Analysis (Lot No. 870129C-25MG-C-011 and 6165CJC011)
- Certificate of Analysis (Lot No. 870129C-25MG-A-012 and 6165CJA012)
- Certificate of Analysis (Lot No. 870129C-25MG-B-012 and 6165CJB012)
- Certificate of Analysis (Lot No. 870129C-25MG-C-012 and 6165CJC012)
- Certificate of Analysis (Lot No. 870129C-25MG-A-013 and 6165CJA013)
- Certificate of Analysis (Lot No. 870129C-25MG-B-013 and 6165CJB013)
- Certificate of Analysis (Lot No. 870129C-25MG-A-014 and 6165CJA014)
- Certificate of Analysis (Lot No. 870129C-25MG-B-014 and 6165CJB014)
