Powered by Bioz
860799 | CP-LC-0729
Please Confirm Your Location
Effective March 1, 2018, Merck KGaA, Darmstadt, Germany* is the exclusive Distributor of Avanti Research. Research Products for all countries except the United States. For product pricing and order placement, please click on the appropriate Location Box below.
For customers located outside the United States, you will be redirected to www.sigmaaldrich.com/avanti prior to completing your purchase. Thank you for your continued business and support of Avanti Research!
*The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada
Info
CP-LC-0729
Manufactured and Distributed under License from Certest Biotec S.L
CP‑LC‑0729 is a next-generation ionizable lipid designed for efficient nucleic acid delivery using lipid nanoparticles (LNPs). Distributed and manufactured by Avanti Research™, this cationic lipid demonstrates superior performance in vivo expression and tolerability, particularly for hepatic and pulmonary delivery applications.
CP-LC-0729 has a measured pKa of 6.78 and promotes effective endosomal escape, an essential mechanism for successful mRNA, saRNA, or circRNA release into the cytosol. Its branched hydrophobic structure supports the formation of stable, homogenous LNPs with high encapsulation efficiency and low polydispersity. It has significantly outperformed benchmark lipids, demonstrably improving expression levels and lowering systemic toxicity (Mata, E., Broset, E., Matute, C. et al. 2025).
Application
CP-LC-0729 has exhibited exceptional performance in liver and lung-targeted expression models, with over 30-fold enhanced gene expression in pulmonary tissues compared to traditional ionizable lipids. This lipid's biodegradable design and favorable safety profile make it even more suitable for repeat dosing in preclinical studies. Furthermore, CP-LC-0729 possesses a unique chemical composition that enables rapid endosomal disruption and cytosolic release to promote robust protein expression with minimal immunogenicity.
Packaging
In partnership with Certest, Avanti Research™ offers CP-LC-0729 as a lyophilized oil in 5mg and 25mg packaging to support various research workflows. Each batch is produced to >99% purity to ensure optimal reproducibility and LNP performance.
With decades of lipid expertise, Avanti Research™ provides high-performance delivery systems to power next-generation therapeutics.
Data
No
No
| C43H85N3O4S |
C 69.77%, H 11.57%, N 5.68%, O 8.65%, S 4.33%
>99%
1 year
-20 °C
CAS Number
3040858-60-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
CAS Registry Number is a Registered Trademark of the American Chemical Society
740.23
739.63
Certificates of Analysis
- Certificate of Analysis (Lot No. 860799O-5MG-A-010 and 7327OHA010)
- Certificate of Analysis (Lot No. 860799O-25MG-A-010 and 7327OJA010)
