860782 | α-Glucosyl FP20
6-O-α-D-Glucopyranosyl-1β,2N,3-tridodecanoyl-D-glucosamine-4-phosphate, sodium salt
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α-Glucosyl FP20
6-O-α-D-Glucopyranosyl-1β,2N,3-tridodecanoyl-D-glucosamine-4-phosphate, sodium salt
FP-20 offers another innovative approach to boosting vaccine efficacy by selectively stimulating Toll-like receptor 4 (TLR4) pathways. The simplicity of FP structures allows for scalable production of highly pure materials, ensuring a reliable and cost-effective supply for vaccine developers. Like VSA, FP adjuvants provide both humoral and cellular immune enhancements but achieve this through a targeted, mechanism-driven approach.For more specialized immune responses, glycosylated FP-20 analogs offer a selective approach, targeting human TLR4 (hTLR4) receptors, which makes them highly effective in fine-tuning immune responses while maintaining safety. As with VSA, FP adjuvants also boast favorable safety profiles, with both in vitro and in vivo studies indicating no significant toxicity.
Glucosyl FP20 (and other FP compounds) have been licensed through a third-party. This compound is intended for research purposes only. If you wish to discuss a potential sub-license, please reach out via email to customerservice@avantilipids.com.
C48H89NNaO16P
C 58.22%, H 9.06%, N 1.41%, Na 2.32%, O 25.85%, P 3.13%
CAS Registry Number is a Registered Trademark of the American Chemical Society
Powered by BiozJ. Med. Chem. 2023, 66, 4, 3010–3029Publication Date:February 2, 2023https://doi.org/10.1021/acs.jmedchem.2c01998
ACS Omega 2023, 8, 39, 36412–36417Publication Date:September 18, 2023https://doi.org/10.1021/acsomega.3c05363
J. Med. Chem. 2021, 64, 16, 12261–12272Publication Date:August 12, 2021https://doi.org/10.1021/acs.jmedchem.1c00896
