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860678 | C24 Ceramide-d7 (d18:1-d7/24:0)

N-lignoceroyl-D-erythro-sphingosine (d7)

C24 Ceramide-d7 (d18:1-d7/24:0)

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C24 Ceramide-d7 (d18:1-d7/24:0)

N-lignoceroyl-D-erythro-sphingosine (d7)

Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease. Avanti has now made available these 4 ceramides in a stable isotope form as a convenience for a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.
Refer: D. Kauhanen et al. (2016). Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem 408:3475-83
Avanti Numbers 860676, 760677, 860678 and 860679 refer.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C42H76D7NO3
Percent Composition
C 76.76%, H 13.80%, N 2.13%, O 7.30%
Purity
>99%
Stability
1 year
Storage Temperature
-20°C
CAS Number
1840942-15-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
657.156
Exact Mass
656.681
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References

Razak Hady H, Błachnio-Zabielska AU, Szczerbiński Ł, Zabielski P, Imierska M, Dadan J, Krętowski AJ. Ceramide Content in Liver Increases Along with Insulin Resistance in Obese Patients. J Clin Med. 2019 Dec 12;8(12):2197. doi: 10.3390/jcm8122197. PMID: 31842461; PMCID: PMC6947381.

 PubMed ID: 31842461

Zulueta Díaz YLM, Menghi K, Guerrero ML, Nocelli N, Fanani ML. l-Ascorbic acid alkyl esters action on stratum corneum model membranes: An insight into the mechanism for enhanced skin permeation. Colloids Surf B Biointerfaces. 2020 Jan 1;185:110621. doi: 10.1016/j.colsurfb.2019.110621. Epub 2019 Nov 2.

 PubMed ID: 31726308

Kaya S, Aslan İ, Kıraç E, Karaarslan T, Aslan M. Serum Sphingolipidomic Analysis in Acne Vulgaris Patients. Ann Clin Lab Sci. 2019 Mar;49(2):242-248.

 PubMed ID: 31028071

Pullmannova P, Ermakova E, Kovacik A, Opalka L, Maixner J, Zbytovska J, Kucerka N, Vavrova K. Long And Very Long Lamellar Phases In Model Stratum Corneum Lipid Membranes. J Lipid Res. 2019 Mar 18. pii: jlr.M090977. doi: 10.1194/jlr.M090977. [Epub ahead of print]

 PubMed ID: 30885924

Kauhanen D, Sysi-Aho M, Koistinen KM, Laaksonen R, Sinisalo J, Ekroos K. Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides. Anal Bioanal Chem. 2016 May;408(13):3475-83. doi: 10.1007/s00216-016-9425-z. Epub 2016 Feb 27.

 PubMed ID: 26922344
Certificates of Analysis

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