860576 | C16 Lactosyl(ß) Ceramide (d18:1/16:0)
D-lactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine
C16 Lactosyl(ß) Ceramide (d18:1/16:0)
D-lactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine
C16 Galactosyl(ß) Ceramide (d18:1/16:0) or D-lactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine, also known as Lactosylceramide, is a glycosphingolipid composed of a sphingosine backbone linked to a lactosyl sugar moiety and a palmitoyl fatty acid chain. This molecule is a critical component of cell membranes, playing a significant role in cell signaling, particularly in processes such as cell differentiation, proliferation, and apoptosis.
Lactosylceramide is predominantly found in the outer leaflet of the plasma membrane and is involved in the formation of lipid rafts, specialized membrane microdomains that serve as platforms for various cellular processes.
Application
C16 Galactosyl(ß) Ceramide’s functions are particularly critical in the nervous system, immune response, and in the development of certain diseases, including cancer and neurodegenerative disorders.
Due to its importance in cellular functions and disease mechanisms, D-lactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine is widely used in research focused on cell biology, specifically cell signaling and membrane structure. In neurobiology, it plays a role in neurodegenerative disease and neural cell functions. Additionally, in immunology, it affects cell signaling and response and has also been shown to impact metabolic processes.
Packaging
Avanti Research provides D-lactosyl-ß-1,1' N-palmitoyl-D-erythro-sphingosine in powder form in 5 mg packaging.
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CAS Registry Number is a Registered Trademark of the American Chemical Society
N-(hexadecanoyl)-1-ß-lactosyl-sphing-4-enine
110761
Powered by BiozBetker JL, Anchordoquy TJ. The Use of Lactose as an Alternative Coating for Nanoparticles. J Pharm Sci. 2020 Jan 28:S0022-3549(20)30026-5. doi: 10.1016/j.xphs.2020.01.019. Epub ahead of print. PMID: 32004536.
PubMed ID: 32004536Fincher JA, Jones DR, Korte AR, Dyer JE, Parlanti P, Popratiloff A, Brantner CA, Morris NJ, Pirlo RK, Shanmugam VK, Vertes A. Mass Spectrometry Imaging of Lipids in Human Skin Disease Model Hidradenitis Suppurativa by Laser Desorption Ionization from Silicon Nanopost Arrays. Sci Rep. 2019 Nov 25;9(1):17508. doi: 10.1038/s41598-019-53938-0.
PubMed ID: 31767918Nejatian N, Trautmann S, Thomas D, Pfeilschifter J, Badenhoop K, Koch A, Penna-Martinez M. Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. J Steroid Biochem Mol Biol. 2019 Feb;186:130-135. doi: 10.1016/j.jsbmb.2018.10.005. Epub 2018 Oct 15.
PubMed ID: 30336275- Certificate of Analysis (Lot No. 860576P-5MG-A-010 and 6020PHA010)
- Certificate of Analysis (Lot No. 860576P-5MG-B-010 and 6020PHB010)
- Certificate of Analysis (Lot No. 860576P-5MG-A-012 and 6020PHA012)
- Certificate of Analysis (Lot No. 860576P-5MG-B-012 and 6020PHB012)
- Certificate of Analysis (Lot No. 860576P-5MG-C-012 and 6020PHC012)
- Certificate of Analysis (Lot No. 860576P-5MG-E-012 and 6020PHE012)
- Certificate of Analysis (Lot No. 860576P-5MG-F-012 and 6020PHF012)
