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860575 | C8 L-threo-Lactosyl(ß) Ceramide (d18:1/8:0)

D-lactosyl-ß1-1'-N-octanoyl-L-threo-sphingosine

C8 L-threo-Lactosyl(ß) Ceramide (d18:1/8:0)

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C8 L-threo-Lactosyl(ß) Ceramide (d18:1/8:0)

D-lactosyl-ß1-1'-N-octanoyl-L-threo-sphingosine

β-D-lactosyl-N-octanoyl-L-threo-sphingosine, (1) selectively inhibits caveolar endocytosis and SV40 virus infection, (2) blocks the clustering of lipids and proteins into GSLs and cholesterol-enriched microdomains (rafts) at the PM, and (3) inhibits β1-integrin activation and downstream signaling. Singh, R.D., E.L. Holicky, Z.J. Cheng, S.Y. Kim, C.L. Wheatley, D.L. Marks, R. Bittman, and R.E. Pagano. (2007). Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer. J Cell Biol 176:895-901.

Data
Hygroscopic
Yes
Light Sensitive
No
Molecular Formula
C38H71NO13
Percent Composition
C 60.86%, H 9.54%, N 1.87%, O 27.73%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
939036-94-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
749.969
Exact Mass
749.493
Synonyms
C8-threo-LacCer
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References

Chen S, Wang J, Wang M, Lu J, Cai Y, Li B. In vitro fertilization alters phospholipid profiles in mouse placenta. J Assist Reprod Genet. 2019 Jan 4. doi: 10.1007/s10815-018-1387-y. [Epub ahead of print]

 PubMed ID: 30610659

Singh, R.D., E.L. Holicky, Z.J. Cheng, S.Y. Kim, C.L. Wheatley, D.L. Marks, R. Bittman,and R.E. Pagano. (2007). Inhibition of caveolar uptake, SV40 infection, andβ1-integrin signaling by a nonnatural glycosphingolipid stereoisomer.J Cell Biol 176:895-901.
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